光強差動式表面電漿共振感測術之研究

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姓名

劉冠彣(Gwan-Wun Liu) 查詢紙本館藏

畢業系所

光機電工程研究所

論文名稱

光強差動式表面電漿共振感測術之研究
(Differential surface plasmon resonance sensing technique)

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摘要(中)

本研究以差動偵測技術結合表面電漿共振技術，開發出一種光強差動式的表面電漿共振（Surface Plasmon Resonance，SPR）偵測技術。本系統由實驗所得的對折射率解析度約為 10-5 RIU。本論文的實驗目的為偵測微小的折射率變化，以及驗證出系統的功能。在實驗上，可分辨出折射率相差0.0001 RIU折射率的不同濃度酒精溶液。本系統具有即時偵測、高靈敏度等優點，預計可應用於微小生物分子鍵結反應的檢測領域上。未來若能應用於生物分子陣列晶片上，將能達到大量平行篩檢的應用上，以求本系統對生醫檢測有所貢獻。

摘要(英)

An optical differential detection technique for the surface plasmon resonance (SPR) sensing is proposed. In our system, we combine a method of differential detection and SPR technique. The measurement sensitivity of refractive index is about 10-5 RIU (Refractive Index Unit). There are several advantages like immediate detection and high sensitivity in our system. This technique can be applied to the small biological molecule interaction. It is expected to combine the biological molecule on bio-chip array for massive parallel screens.

關鍵字(中)

★ 差動偵測
★ 表面電漿共振

關鍵字(英)

★ differential detection
★ Surface plasmon resonance

論文目次

摘要 I
Abstract II
目錄 IV
圖目錄 VI
表目錄 IX
符號說明 X
第一章緒論 - 1 -
1-1 前言 - 1 -
1-2 文獻回顧 - 3 -
1-3 研究動機與目的 - 7 -
1-4 論文架構 - 8 -
第二章差動表面電漿共振原理 - 10 -
2-1 表面電漿共振原理 - 10 -
2-2 激發表面電漿波的方式 - 11 -
2-3表面電漿共振反射光強度與入射角的關係 - 14 -
2-4 反射光強度差動偵測原理 - 17 -
2-5 小結 - 23 -
第三章系統設計與架構 - 24 -
3-1 感測片參數設計 - 24 -
3-2 機構設計 - 28 -
3-3 整體架構 - 31 -
3-4 程式設計 - 35 -
3-5 小結 - 40 -
第四章實驗結果與討論 - 41 -
4-1 實驗準備 - 41 -
4-2 實驗一:小範圍酒精濃度測試 - 48 -
4-3 實驗二:大範圍酒精濃度測試 - 51 -
4-4 誤差來源與分析 - 54 -
4-5 系統解析度分析 - 61 -
4-6 小結 - 63 -
第五章結論 - 64 -
參考文獻 - 65 -

參考文獻

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指導教授

李朱育(Ju-yi Lee)

審核日期

2008-7-17

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