慢性阻塞性肺疾病病患在失智症增加的風險及相關因素:以台灣全人口基礎的前瞻式世代研究

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姓名

陳俊宏(Chun-Hung Chen) 查詢紙本館藏

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資訊工程學系在職專班

論文名稱

慢性阻塞性肺疾病病患在失智症增加的風險及相關因素:以台灣全人口基礎的前瞻式世代研究
(Increased risk and related factors of dementia among chronic obstructive pulmonary disease patients: A population-based prospective cohort study in Taiwan)

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摘要(中)

慢性阻塞性肺病（COPD）是一種慢性發炎所造成的呼吸道阻塞疾病，除了本身的肺部效應外，還伴隨著顯著的肺外效應，如:營養不良、骨骼肌功能障礙、中樞神經系統損害等。近年研究顯示，慢性阻塞性肺病增加了對輕度認知障礙（MCI）的風險，而輕度認知障礙每年則約有10%至15%轉變成失智症。因此，本研究擬利用台灣全民健保研究資料庫之資料，針對50歲以上的病患探討慢性阻塞性肺病患是否比非慢性阻塞性肺病患增加失智症的風險。研究結果顯示，慢性阻塞性肺病患與非慢性阻塞性肺病患相比，慢性阻塞性肺病患有顯著增加失智症風險 (HR =2.05, 95% CI=1.88-2.22)。其中罹患阿茲海默症和非阿茲海默失智症的風險各為(HR =2.16, 95% CI=1.97-2.37)和(HR =1.64, 95% CI=1.35-1.98) ，均有顯著增加的風險。

摘要(英)

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease caused by airway obstruction, in addition to the lungs effects itself, but also be accompanied by a significant extra-pulmonary effects, such as: malnutrition, skeletal muscle dysfunction, central nervous system damage, etc. Recent studies have shown that chronic obstructive pulmonary disease increases the risk of mild cognitive impairment (MCI), and mild cognitive impairment each year and about 10-15% into dementia. Therefore, this study intends to use the information in Taiwan National Health Insurance Research Database for patients over 50 years old to explore whether patients with chronic obstructive pulmonary increased risk of dementia than non-chronic obstructive pulmonary patients. The results showed that patients with chronic obstructive pulmonary compared with non-chronic obstructive pulmonary patients suffering from chronic obstructive pulmonary disease significantly increases the risk of dementia (HR = 2.05, 95% CI= 1.88-2.22). Where the risk of suffering from Alzheimer′s disease and non-Alzheimer′s dementia each (HR = 2.16, 95% CI=1.97-2.37) and (HR = 1.64, 95% CI=1.35-1.98), were significantly increased risk.

關鍵字(中)

★ 慢性阻塞性肺疾病
★ 失智症
★ 阿茲海默症
★ 世代研究

關鍵字(英)

★ COPD
★ dementia
★ Alzheimer′s disease
★ cohort study

論文目次

摘要 i
ABSTRACT ii
誌謝 iii
Table of Contents iv
List of Figures v
List of Tables vi
Chapter 1 Introduction 1
1.1 Background 1
1.2 Motivation 2
1.3 Research Goal 2
Chapter 2 Related Works 3
2.1 Chronic Obstructive Pulmonary Disease 3
2.2 COPD and Dementia 4
Chapter 3 Materials and Methods 6
3.1 Data Source 6
3.2 Study Design and Cohort Selection 6
3.3 Definition of disease 8
3.4 Confounding Factors 9
3.5 Statistical Analysis 10
Chapter 4 Results 12
4.1 Demographic Characteristics 12
4.2 Incidence Rate and Risk of Dementia between Two Cohorts 14
4.3 Relative Risk of Dementia among COPD Cohorts 17
4.4 Kaplan-Meier Dementia-Free Curves 25
4.5 Multiple Logistic Regression Model 28
Chapter 5 Discussion 30
Chapter 6 Conclusion 33
References 34
Appendix I Charlson-Deyo Comorbidity Index 37

參考文獻

1.Pauwels RA, Rabe KF. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet. 2004 Aug 14-20; 364(9434): 613-20.
2.Halbert RJ, Natoli JL, Gano A, Badamgarav E, Buist AS, Mannino DM. Global burden of COPD: systematic review and meta-analysis. Eur Respir J. 2006 Sep; 28(3): 523-32.
3.Villeneuve S, Pepin V, Rahayel S, et al. Mild cognitive impairment in moderate to severe COPD: a preliminary study. Chest. 2012 Dec; 142(6): 1516-23.
4.Crişan AF, Oancea C, Timar B, Fira-Mladinescu O, Crişan A, Tudorache V. Cognitive impairment in chronic obstructive pulmonary disease. PLoS One. 2014 Jul 17; 9(7).
5.Kumar Amit, Vandana. REVIEW ARTICLE DEMENTIA: AN OVERVIEW. Journal of Drug Delivery & Therapeutics; 2013, 3(3), 163-167.
6.Boeve BF. A review of the non-Alzheimer dementias. J Clin Psychiatry. 2006 Dec; 67(12): 1985-2001.
7.Busse A, Angermeyer MC, Riedel-Heller SG. Progression of mild cognitive impairment to dementia: a challenge to current thinking. Br J Psychiatry. 2006 Nov; 189: 399-404.
8.Gerhard W Eschweiler, Thomas Leyhe, Stefan Klöppel, Michael Hüll. New Developments in the Diagnosis of Dementia Dtsch Arztebl Int. Oct 2010; 107(39): 677–683.
9.Singh B, Mielke MM, Parsaik AK, et al. A prospective study of chronic obstructive pulmonary disease and the risk for mild cognitive impairment. JAMA Neurol. 2014 May; 71(5): 581-8.
10.Antonelli-Incalzi R, Corsonello A, Pedone C, Trojano L, Acanfora D, Spada A, Izzo O, Rengo F. Drawing impairment predicts mortality in severe COPD. Chest. 2006 Dec; 130(6): 1687-94.
11.Dodd JW1, Getov SV, Jones PW. Cognitive function in COPD. Eur Respir J. 2010 Apr; 35(4): 913-22.
12.Schou L, Østergaard B, Rasmussen LS, Rydahl-Hansen S, Phanareth K. Cognitive dysfunction in patients with chronic obstructive pulmonary disease--a systematic review. Respir Med. 2012 Aug; 106(8): 1071-81.
13.Singh B, Parsaik AK, Mielke MM, et al. Chronic obstructive pulmonary disease and association with mild cognitive impairment: the Mayo Clinic Study of Aging. Mayo Clin Proc. 2013 Nov; 88(11): 1222-30.
14.Rusanen M, Ngandu T, Laatikainen T, Tuomilehto J, Soininen H, Kivipelto M. Chronic obstructive pulmonary disease and asthma and the risk of mild cognitive impairment and dementia: a population based CAIDE study. Curr Alzheimer Res. 2013 Jun; 10(5): 549-55.
15.W.-C. Liao, C.-L. Lin, S.-N. Chang, C.-Y. Tu and C.-H. Kao. The association between chronic obstructive pulmonary disease and dementia: a population-based retrospective cohort study. European Journal of Neurology 2014, 0: 1–7
16.Rabe KF, Hurd S, Anzueto A, el al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2007 Sep 15; 176(6): 532-55.
17.Li J, Huang Y, Fei GH. The evaluation of cognitive impairment and relevant factors in patients with chronic obstructive pulmonary disease. Respiration. 2013; 85(2): 98-105.
18.National Health Insurance Database: LHID Backgroud; 2014. http://nhird.nhri.org.tw/en/.
19.Corrada MM, Brookmeyer R, Paganini-Hill A, Berlau D, Kawas CH. Dementia incidence continues to increase with age in the oldest old: the 90+ study. Ann Neurol. 2010 Jan; 67(1):114-21.
20.Xu WL, Atti AR, Gatz M, Pedersen NL, Johansson B, Fratiglioni L. Midlife overweight and obesity increase late-life dementia risk: a population-based twin study. Neurology. 2011 May 3; 76(18): 1568-74.
21.Tzung-Yi Tsai, Hanoch Livneh, Ming-Chi Lu, et al. Increased risk and related factors of depression among patients with COPD: a population-based cohort study. BMC Public Health 2013, 13: 976
22.Wang MT, Tsai CL, Lo YW, Liou JT, Lee WJ, Lai IC. Risk of stroke associated with inhaled ipratropium bromide in chronic obstructive pulmonary disease: a population-based nested case-control study. Int J Cardiol. 2012 Jul 12; 158(2):279-84.
23.Romano PS, Roos LL, Jollis JG. Adapting a clinical comorbidity index for use with ICD-9-CM administrative data: differing perspectives. J Clin Epidemiol. 1993 Oct; 46(10): 1075-9.
24.Cramer C, Haan MN, Galea S, Langa KM, Kalbfleisch JD. Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study. Neurology. 2008 Jul 29; 71(5): 344-50.
25.Jonker C, Comijs HC, Smit JH. Does aspirin or other NSAIDs reduce the risk of cognitive decline in elderly persons? Results from a population-based study. Neurobiol Aging. 2003 Jul-Aug; 24(4): 583-8.
26.Hsu C-C, Wahlqvist ML, Lee M-S, Tsai H-N. Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin. Journal of Alzheimer′s disease. 02/2011; 24(3): 485-93.
27.Johnson ML, Parikh N, Kunik ME, et al. Antihypertensive drug use and the risk of dementia in patients with diabetes mellitus. Alzheimers Dement. 2012 Sep; 8(5): 437-44.
28.Sara C Hitchman,Geoffrey T Fong Gender empowerment and female-to-male smoking prevalence ratios. Bulletin of the World Health Organization 2011; 89: 195-202.
29.Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study. Ann Neurol. 2002 Aug; 52(2): 168-74.
30.Engelhart MJ, Geerlings MI, Meijer J, et al. Inflammatory proteins in plasma and the risk of dementia: the rotterdam study. Arch Neurol. 2004 May; 61(5): 668-72.
31.Kalaria RN, Maestre GE, Arizaga R, et al. Alzheimer′s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol. 2008 Sep; 7(9): 812-26.
32.Wysocki M1, Luo X, Schmeidler J, Dahlman K, et al. Hypertension is associated with cognitive decline in elderly people at high risk for dementia. Am J Geriatr Psychiatry. 2012 Feb; 20(2): 179-87.
33.Modrego PJ, Ferrández J. Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study. Arch Neurol. 2004 Aug; 61(8): 1290-3.
34.Pendlebury ST, Rothwell PM. Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. Lancet Neurol. 2009 Nov; 8(11): 1006-18.
35.Qiu C, Winblad B, Marengoni A, Klarin I, Fastbom J, Fratiglioni L. Heart failure and risk of dementia and Alzheimer disease: a population-based cohort study. Arch Intern Med. 2006 May 8; 166(9): 1003-8.
36.Chang KH1, Chung CJ, Lin CL, Sung FC, Wu TN, Kao CH. Increased risk of dementia in patients with osteoporosis: a population-based retrospective cohort analysis. Age (Dordr). 2014 Apr; 36(2): 967-75.
37.Xu WL, von Strauss E, Qiu CX, Winblad B, Fratiglioni L. Uncontrolled diabetes increases the risk of Alzheimer′s disease: a population-based cohort study. Diabetologia. 2009 Jun; 52(6): 1031-9.
38.Pearce JM. Brain disease leading to mental illness: a concept initiated by the discovery of general paralysis of the insane. Eur Neurol. 2012; 67(5): 272-8.

指導教授

洪炯宗(Jorng-Tzong Horng)

審核日期

2015-1-27

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