頻域式擴散光學造影之乳房掃描暨量測系統研究

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游釗銘(Jhao-Ming Yu) 查詢紙本館藏

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光機電工程研究所

論文名稱

頻域式擴散光學造影之乳房掃描暨量測系統研究

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摘要(中)

近紅外光擴散光學成像(near infrared diffuse optical imaging, NIR DOI)是新穎的功能性醫學造影技術，其檢測機制乃藉個別組織(如皮膚、脂肪、及腦灰質等)光學特性差異，以及病變組織血紅素濃度增加、含氧飽和程度降低等，致NIR特定波段的光吸收、散射特性有所差異，以此區分組織之變異狀況。因台灣乳癌發生率及死亡率逐年提升，且基於早期發現對治療及預後有正面幫助，故本研究藉由設計三維環形掃描裝置，結合頻域式光學量測技術，建立應用於乳癌檢測之俯臥式擴散光學斷層掃描造影系統。
環形檢測裝置之掃描模式採mZnS設計，藉由光源與光偵測器通道配置，使適度減少檢測過程所需掃描角度，進而降低檢測時間。此裝置藉由徑向同動機構設計，可依不同乳房幾何外型，完成直徑50mm至150mm範圍及垂直軸150mm之斷層掃描範圍；另外，光學量測上，採用強度調變頻率20MHz之單波長光源輸入乳房，並透過光電倍增管擷取其表面逐點輸出之光學資訊並轉成電訊號，再藉混波器調變及解調過程獲得各檢測點之幅值及相位特徵，最後再藉由中大D-BioM實驗室發展之光學係數影像重建軟體NIRFD_PC-r重建乳房內部之光學影像。本光學量測系統乃透過光電訊號校正程序，使提高系統輸出訊號穩定性。本研究藉由80mm仿乳房光學係數假體實驗，完成檢測系統對仿體之幾何及光學特徵驗證，並透過斷層掃描施作完成嵌入式腫瘤仿體檢測驗證。
基於本研究發展之臥床式擴散光學斷層掃描系統，以功能性成像、頻域式量測及非接觸掃描等特點，可望提高乳房病灶之檢知率及受檢者之接受度，進而增加篩檢率。

摘要(英)

Breast cancer has long-term remained the highest incidence rate, and the 4th highest mortality rate for woman in Taiwan. Based on routine X-ray breast mammography, relatively safe near infrared diffuse optical imaging (NIR DOI) is emerging as a potential imaging technique for breast cancer detection. Compared with the mammography which gives only the structural images of breast tissue, DOI provides not only the structural information, but also the functional images including oxyhemoglobin, deoxyhemoglobin, lipid and water content as well as the morphological images including nucleus size and volume fraction. This research project aims to obtain structural, functional and morphological contents of breast tissue using a multi-spectral DOI image reconstruction approach.
In this study, we propose and implement three-dimensional (3-D) ring-scanning equipment for near-infrared (NIR) diffuse optical imaging to screen breast tumors under prostrating examination. This equipment has the function of the radial, circular, and vertical motion without compression of breast tissue, thereby achieving 3-D scanning; furthermore, a flexible combination of mZnS design of illumination and detection can be configured for the required resolution. The research proceeds to the development of prostrate-type DOI system based on previous basis, such as frequency-domain measurement system, inverse computation scheme for optical-property images, and algorithms for the purpose of rapid convergence, edge-preserving for better tumor detection. Results of this study showed phantom experiment confirmed that the 3-D scanning system can distinguish the geometric and optical characteristics difference between tumors and background.

關鍵字(中)

★ 近紅外光擴散光學成像
★ 三維環形掃描
★ 頻域式光學量測
★ 俯臥式
★ mZnS
★ 光學係數影像
★ 仿乳假體驗證

關鍵字(英)

★ NIR DOI
★ 3-D ring-scanning
★ mZnS
★ prostrate-type
★ frequency-domain measurement
★ optical-property images
★ phantom experiment

論文目次

摘要 I
Abstracts II
致謝 III
目錄 VII
圖目錄 IX
表目錄 XIII
第一章緒論 1
1-1 研究動機與目的 1
1-2 文獻探討 3
1-2-1 光學檢測技術 3
1-2-2 光訊號擷取平台 4
1-3 研究範疇 6
第二章理論基礎 8
2-1 乳房組織光學特性 8
2-2 組織擴散光學量測 11
2-2-1頻域式量測系統分析 13
2-2-2光學掃描模式 15
2-3 頻域式擴散光學影像重建 17
2-3-1 頻域式量測 18
2-3-2 光學係數影像重建法 20
第三章環形掃描裝置設計製作 24
3-1 掃描模組設計 24
3-1-1 光通道徑向位移機構設計 25
3-1-2 機台運動控制設計 29
3-2 系統操作與控制 31
3-2-1 機台運動操作時間 32
3-2-2 系統檢測程序 34
3-2-3 掃描機台操控/量測人機介面 35
3-3 仿乳房光學特性假體 37
第四章頻域式擴散光學量測 39
4-1 系統架構 39
4-2 光電元件特性與測試 40
4-2-1 光源端元件 40
4-2-2 光偵測器端元件 42
4-2-3 電訊號處理元件 50
4-3 檢測系統校正 54
4-3-1 多光偵測器應用 54
4-3-2 光電檢測系統校正 55
4-3-3 標準仿體校正 57
第五章檢測驗證與結果討論 60
5-1 仿乳假體實驗設計 60
5-2 結果分析與討論 61
第六章結論與未來展望 66
6-1結論 66
6-2 未來展望 67
參考文獻 68
附錄A、頻域式檢測系統訊號分析 76
附錄B、環形掃描模式設計 79
研究成果發表 82
個人簡歷 85

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指導教授

潘敏俊(Min-Chun Pan)

審核日期

2015-10-1

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