運用光體積血容積於血流介導擴張於動脈內皮細胞舒張功能研究

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姓名

朱祐賢(Yu-Hsien Chu) 查詢紙本館藏

畢業系所

電機工程學系

論文名稱

運用光體積血容積於血流介導擴張於動脈內皮細胞舒張功能研究
(Studying the feasibility of using PPG flow-mediated dilation to evaluate artery endothelium function)

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摘要(中)

心血管疾病已經多年位居十大死亡原因前五位，相關臨床徵兆包含動脈硬化、高血壓、內皮組織異常等。而隨著醫學進步及血管內皮細胞釋放一氧化氮的發現，科學家對於心血管疾病之成因及動脈硬化過程有更進一度的了解，而內皮細胞的損傷，將會導致動脈血管的內壁發炎反應，引起動脈粥狀硬化。因此如何評估內皮功能以預防心血管疾病，將是居家健康照護重要的一塊。由於內皮功能是一種可逆性的反應[1]，因此我們可以藉由改變生活習慣如戒菸、運動和飲食習慣來恢復血管內皮細胞之正常，另外藥物治療以及賀爾蒙療法也都是可行的方法[2]。

一般而言，評估內皮細胞需應用Flow- mediated dilatation (FMD)的方法，藉由在手臂或上臂給予約200mmHg的壓力，觀察血管阻斷後恢復之管徑擴張變化。傳統使用高解析度的超音波儀器並搭配2D彩色影像顯示軟體來觀察因FMD所引起的血管直徑改變，雖然許多學者認會此方法具有較好準確性跟重現性，是目前醫院最常使用的量測方法，但高價格與需要專業人士操作則是FMD的兩大缺陷[3]。因此本研究採用光體積變化描記圖(Photoplethysmography，PPG)綠光來評估內皮情況，讓大家可以方便地隨時偵測自己的內皮情況是此研究的目標。

摘要(英)

In past years the mortality caused by cardiovascular diseases (CVD) ranked high in top one causes mortality in Taiwan, clinical signs including atherosclerosis, high blood pressure, endothelial dysfunction etc. With medical progress and discovery of NO, we have further understanding of the cause of CVD and atherosclerosis. And vascular endothelial injury leading to vascular inflammation induces atherosclerosis. Therefore how to assess the endothelial function to prevent CVD is an important part of home care. Because of endothelial function is a reversible reaction [1]. Then we could recover endothelial function by changing habits, like quit smoking, exercise, and diet. Hormone replacement therapy and medicine are also the solutions [2].
Generally, the common approach to endothelial function assessment is Flow- mediated dilatation (FMD). FMD is the method by boosting to 200mmHg on arm and observing vascular diameter after blocking blood vessels. FMD ratio was defined by BAUS as the ratio of the brachial artery diameter during reactive hyperemia relative to the baseline. Although it is generally considered that FMD has better accuracy and reproducibility, also FMD is commonly used by hospital. However there are two flaws: expensive and technical threshold. In this study, we use greenlight Photoplethysmography (PPG) to assess endothelial function. Creating a convenient way to assess endothelial function is the goal of this study.

關鍵字(中)

★ 內皮功能
★ FMD
★ 一氧化氮

關鍵字(英)

★ Endothelial Function
★ flow-induced arterial vasodilation
★ NO

論文目次

摘要 Ⅱ
ABSTRACT Ⅲ
誌謝 Ⅳ
目錄 Ⅴ
圖目錄 Ⅶ
表目錄 Ⅸ
第一章緒論 1
1-1 前言 1
1-2 文獻回顧 2
1-3 血管內皮細胞功能量測方法回顧 3
第二章原理簡介 6
2-1 生理原理簡介 6
2-1-1 PPG原理簡介 6
第三章研究設計與方法 8
3-1 系統架構 8
3-1-1 硬體架構 8
3-1-2. 韌體撰寫過程 11
3-2. 實驗設計 14
3-2-1. 實驗步驟 14
3-2-2. 超音波流程. 15
3-2-3. 演算法架構 17
第四章結果與討論 21
4-1 實驗結果 21
4-2 結果討論 29
第五章未來期望 30
參考文獻 31

參考文獻

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指導教授

李柏磊(Po-Lei Lee)

審核日期

2016-8-29

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