全面性尋找類風濕性關節炎之關聯疾病

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姓名

邱于倫(Yu-Lun Chiu) 查詢紙本館藏

畢業系所

資訊工程學系

論文名稱

全面性尋找類風濕性關節炎之關聯疾病
(Using Association Rules to Comprehensively Scan Diseases Associated With Rheumatoid Arthritis)

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摘要(中)

全面性尋找類風濕性關節炎之關聯疾病
研究生：邱于倫指導教授：洪炯宗博士、吳立青博士
國立中央大學資訊工程研究所
摘要
類風濕性關節炎(Rheumatoid Arthritis)是一種慢性炎症的自體免疫疾病。主要在女性及老年患者居多。在臺灣，罹患類風性關節炎女性大約是男性的4倍，而女性的發病年齡在40-60歲。類風濕性關節炎主要長期影響關節的持續性疾病，一般症狀為關節發熱、腫脹和疼痛。類風濕性關節炎患者不在早期確診治療，患者會遭受到持續性及永久性骨骼關節毀壞、降低生活品質，甚至減少壽命。本論文目的是利用關聯式規則分析來全面性掃描疾病與類風濕性關節炎的相關性。我們通過搜索相關研究來驗證關聯式規則分析結果的準確性。經過驗證後，發現我們研究結果確實可達到與驗證的論文結果有一致的方向性。

摘要(英)

Using Association Rules to Comprehensively Scan Diseases Associated With Rheumatoid Arthritis
Student: Yu-Lun Chiu
Advisor: Dr. Jorng-Tzong Horng, Dr. Li-Ching Wu

Institute of Computer Science and Information Engineering,
National Central University, Taiwan
ABSTRACT
Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. The common patients in women and the elderly. The age of onset is 40-60 years old in women. Patients with rheumatoid arthritis, if not in the early diagnosis and treatment, patients will suffer from persistent and permanent bone and joint damage, reduce the quality of life, or even reduce life. The aim of this study uses the association rule analysis to comprehensively scan the association of disease with rheumatoid arthritis.
Method: Based on NHIRD of the registration files and original claim data, the patients 30 years of age with rheumatoid arthritis. After using the International Classification of Diseases (ICD-9-CM) grouping the disease, the relative risk is calculated for each classification of diseases. Then, the data compiled into a WEKA required format, do the association rule to find out the relevance of the disease.
Result: Most of the results are consistent with the association of RA and disease in the known literature. Such as tuberculosis-related diseases, thyroid-related diseases, gout, autoimmune diseases, iron deficiency anemia, temporomandibular Joint disorders are associated with RA. Also found that some diseases associated with RA, but there is no literature to explore a single disease or at the same time suffering from a relationship between the two diseases and RA. Such as dehydration, hypokalemia, leukopenia, and Raynaud′s syndrome and SLE / SS are associated with RA.
Conclusion: We search the relevant research to verify the accuracy of the association rule analysis results and discover the relevance of the disease to the target disease.
Index terms－ Rheumatoid Arthritis, Comprehensive scanning, Association rule

關鍵字(中)

★ 類風溼性關節炎
★ 廣泛搜尋
★ 關聯法則

關鍵字(英)

★ Rheumatoid Arthritis
★ Comprehensive scanning
★ Association rule

論文目次

摘要 i
ABSTRACT ii
Table of Contents iii
List of Figures iv
List of Tables v
Chapter 1. Introduction 1
1.1 Background 1
1.2 Motivation 2
1.3 Goal 2
Chapter 2. Related Works 3
2.1 Rheumatoid Arthritis 3
2.2 Data Mining 3
2.3 Associative Rules Method 4
Chapter 3. Materials and Methods 6
3.1 Data Sources 6
3.2 Data Pre-processing 9
3.3 Statistical Software 9
Chapter 4. Results 11
4.1 Demographic Characteristics 11
4.2 The Relative Risk of Disease in ICD-9-CM Coding System 11
4.3 RA Risk Patterns of Associative Rule 17
Chapter 5. Discussions and Conclusions 29
5.1 Discussions 29
5.2 Conclusions 32
References 33

參考文獻

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指導教授

洪炯宗、吳立青(Jorng-Tzong Horng Li-Ching Wu)

審核日期

2017-7-26

推文