| 摘要(英) |
The use of cyclotrons to accelerate protons via the bombardment of target substances to produce nuclear reactions has been widely used in the production of artificial radioisotopes, in which the radioisotope fluorine-18 can be made into various types of cancer diagnostic drugs, and thus attracted attention from all walks of life.
The design of the irradiation target has a significant effect on the improvement of the yield of fluorine-18. The designer usually encounters two critical yet conflicting problems during the production process, i.e., corrosion resistance and heat dissipation. Owing to the strong corrosive nature of the fluoric acid, it is necessary to find a target material that is resistant to fluoric acid. In the meantime, a target material should also possess a good heat transfer capability to minimize the overheating phenomenon during the irradiation. However, the existing materials typically cannot meet both requirements simultaneously.
The aim of this study is to design a radiation target system that can operate stably under high power conditions and attempt to sputter a layer of corrosion-resistant tantalum on top of the silver target in an attempt to concurrently achieve good corrosion and heat dissipation.
After the actual irradiation experiment, it has been confirmed that the irradiation target system of this study can run stably under the total power of 1020 (W) and can reach 80% theoretical yield. However, the sputtered tantalum layer undergoes peeling during the irradiation experiment, which clearly indicates the poor adhesion between the silver substrate and sputtered tantalum layer. Therefore, finding the proper intermediate layers to significantly promote the adhesion will be the focus of future research. Neutron flux experiment results, failed to determine the presence of oxygen-18 water in the target cavity, the need for additional experiments in order to obtain further conclusions. |
| 參考文獻 |
(1) PEEPLES, JOHANNA LOUISE. “Design and Optimization of Thermosyphon Batch Targets for Production of 18F”. North Carolina State University. Raleigh, North Carolina: 2004.
(2) Marc S. B., Ken W. V., Bonnie B.,”High-yield, low-pressure [18O] water targets of titanium and niobium for F-18 production on MC-17 cyclotrons”. Applied Radiation and Isotopes 57 (2002)303-308.
(3) K. Gagnon, J.S. Wilson, E. Sant, C.J. Backhouse, S.A. McQuarrie.” Assessing the performance and longevityofNb, Pt, Ta, Ti, Zr, and ZrO2-sputtered Havarfoils for the high-power production of reactive[18F]F by proton irradiation of [18O]H2O”. Applied Radiation and Isotopes 69(2011)1330-1336.
(4) “TR30 Training Manuals”,Ebco Technologies Inc,(1992).
(5) 迴旋加速器. (2016, January 16). Retrieved from維基百科, 自由的百科全書: Retrieved May 01, 2017
https://zh.wikipedia.org/w/index.php?title=%E5%9B%9E%E6%97%8B%E5%8A%A0%E9%80%9F%E5%99%A8&oldid=38773380
(6) 魏明通：核化學，台北，五南圖書出版(股)，2005年版。
(7) James F. Ziegler , M.D. Ziegler, J.P. Biersack.”SRIM-The stopping and range of ions in matter (2010)”.Nuclear Instruments and Methods in Physics Research B 268 (2010) 1818–1823
(8) Bong Hwan Hong ,Tea Gun Yang , In Su Jung , YeunSoo Park , HyungHee Cho. “Visualization experiment of 30 MeV proton beam irradiated water target”.Nuclear Instruments and Methods in Physics Research A 655(2011) 103-107
(9) Roberts AD, Daniel LC and Nickles RJ. “A high power target for production of [18F]fluoride,” Nuclear Instruments and Methods in Physics Research B, vol. 95, 1995.
(10) Zeisler SK, Becker DW, Pavan RA, Moschel R and Rühle H. “A water-cooled spherical niobium target for the production of [18F]fluoride,” Applied Radiation and Isotopes, vol. 53, 2000.
(11) Alvord CW, Williamson AC, Graves TL and Zigler SS. “Design, test and widespreadimplementation of a compact kilo-Watt fluoride ion target,” Nuclear Instruments andMethods in Physics Research B, vol. 241, 2005.
(12) Strangis R and Lepera CG. “RELIABLE FLUORINE-18 [18F-] PRODUCTION AT HIGH BEAM POWER,” Proceedings of the Eighteenth International Conference on Cyclotrons and their Applications. Giardini Naxos, Italy: 2007.
(13) Experimental Nuclear Reaction Data(EXFOR). Retrieved May 01, 2017, from https://www-nds.iaea.org/exfor/exfor.htm |
[Endnote RIS 格式]
[相關文章]
[文章引用]
[完整記錄]
[館藏目錄]
[檢視]
plurk
funp
live
udn
HD
myshare
netvibes
friend
youpush
delicious
baidu
Google bookmarks
del.icio.us
hemidemi
facebook
twitter
google
reddit