博碩士論文 93225015 詳細資訊




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姓名 楊政學(Cheng-Hsueh Yang)  查詢紙本館藏   畢業系所 統計研究所
論文名稱 成對右設限資料檢定之研究
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摘要(中) 摘要
本文針對具右設限的成對存活資料,提出調整成對資料相關性的成對對數秩近似檢定及成對限制平均壽命差異的近似檢定。除以實例說明其應用,並且採用模擬方法研究其型I誤差率及檢定力表現。本文研究具右設限的相關成對存活資料中兩個處理效應的比較。我們提出經過相關性調整後的對數秩檢定與限制平均存活時間差異的檢定。本文除以一個實例說明檢定的應用,也以模擬方法研究所提檢定方法的型I誤差率及檢定力表現。
摘要(英) Abstract
In this article, we are concerned with the problem of comparing two treatment effects when correlated paired survival data are subjected to random right-censorship. The logrank test and the test based on the difference of two restricted mean survival time adjusted by the survived correlation are proposed. A real dataset is illustrated for the use of the tests and a simulation study is conducted to investigate the Type-I error and power performances of the proposed tests.
論文目次 第一章 緒論………………………………………… 1
1.1 研究動機及目的………………………1
1.2 文獻回顧…………………………………3
第二章 統計方法……………………………………… 9
2.1 對數秩檢定…………………………… 9
2.2 限制平均存活時間差異檢定……………… 10
第三章 模擬研究…………………………………… 13
3.1 模擬方法………………………………… 13
3.2 模擬結果……………………………… 14
第四章 實例分析…………………………………… 16
第五章 結論與討論………………………………… 18
參考文獻……………………………………………… 19
附錄一 對數秩檢定統計式之近似變異數…………… 22
附錄二 對數秩檢定統計式之變異數………………… 24
參考文獻 參考文獻
1. Anderson P. K. , Gill R. D. and Kidding N. (1982). Linear nonparametric tests for comparison of counting process with application to censored survival data(with discussion). International Statistical Review 50, 219-258.
2. Elveback, L. (1958). Estimation of survivorship in chronic disease: the ‘actuarial’ method. Journal of the American Statistical Association 53, 420-440.
3. Fleming T. R., Harrington D. P., and O’Sullivan M. (1987) Supremum Versions of the Log-Rank and generalized Wilcoxon statistics. Journal of the American Statistical Association 82, 312-320.
4. Fleming T. R. and Harrington D. P. (1991). Counting Processes and Survival Analysis, Wiley: New York.
5. Gehan, E. A. (1965). A generalized Wilcoxon test for comparing arbitrarily singly censored samples. Biometrika 52, 203-223.
6. Harrington D. P. and Fleming T. R. (1982). A class of rank test procedures for censored survival data. Biometrika 69, 133-143.
7. Holt, J. D. and Prentice, R. L. (1974). Survival analysis in twin studies and matched pairs experiments. Biometrika 61, 17-30.
8. Jung S.H. (1999). Rank tests for matched survival data. Lifetime Data Analysis 5, 67-79.
9. Karrison T. (1987). Restricted mean life with adjustment for covariates. Journal of the American Statistical Association 82, 1169-1176.
10. Karrison T. (1997). Use of Irwin’s Restricted mean life as an Index for comparing survival in different treatment groups. Controlled Clinical Trials 18, 151-167.
11. Kaplan E. L. and Meier P. (1958). Nonparametric estimator from incomplete observations. Journal of the American Statistical Association 53, 457-481.
12. Mantel, N. (1966). Evaluation of survival dataand two new rank order statistics, Cancer Chemotherapy Reports, 50, 163-170.
13. Murray, S. and Cole, B. (2000). Nonparametric rank-based methods for group sequential monitoring of paired censored survival data. Biometrics 56, 984-991.
14. Murray S. (2001). Using weighted Kaplan-Meier statistics in nonparametric comparisons of paired censored survival outcomes. Biometrics 57, 361-368.
15. O’Brien, P. C. and Fleming, T. R. (1987). A paired Prentice-Wilcoxon test for censored paired data. Biometrics 43, 169-180.
16. Pepe M. S. and Fleming T. R. (1989). Weighted Kaplan-Meier Statistics:A class of distance tests for censored survival data. Biometrics 45, 497-507.
17. Peto R. and Peto J. (1972). Asymptotically efficiently rank invariant test procedures. Journal of the Royal Statistical Society Ser. A 135, 185-206.
18. Woolson R. F. and O’Gorman T. W. (1992). A comparison of several tests for censored paired data. Statistics in Medicine 11, 193-208.
19. Woolson R. F. and Lachenbruch P. A. (1980). Rank tests for censored matched pairs. Biomatrika 67, 597-606.
20. Ying Z. and Wei L. J. (1994).The Kaplan-Meier estimate for dependent failure time observartions. Journal of Multivariate Analysis 50, 17-29.
21. Zucker D. M. (1998). Restricted mean life with covariates: modification and extension of a useful survival analysis method. Journal of the American Statistical Association 93, 702-709.
指導教授 陳玉英(Yuh-Ing Chen) 審核日期 2006-6-22
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