藉由結晶製程製備高水溶性化合物： 十二烷基硫酸鈉（SDS） 以及控制其水合物

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姓名

游佳憲(Jia-Xian You) 查詢紙本館藏

畢業系所

化學工程與材料工程學系

論文名稱

藉由結晶製程製備高水溶性化合物：十二烷基硫酸鈉（SDS）以及控制其水合物
(Preparation and Hydrate Control for Highly Water Soluble Compound : Sodium Dodecyl Sulfate (SDS) by Crystallization Processes)

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摘要(中)

十二烷基硫酸鈉(SDS)為高水溶性化合物，並且為常用的表面活性劑之一。在文獻報導中，十二烷基硫酸鈉具有4種水合物，分別為1/8水、半水、一水以及無水。但是製成端方面較少文獻提到如何控制SDS為何種水合物。因此本篇論文主要目的為採取工業上常用批式結晶，並結合蒸發結晶、反溶劑結晶以及冷卻結晶製造出特定SDS·1/8水合物。買來的0.5克SDS以定量的方式浸泡在由水及丙酮組成的1比17之體積比的共溶劑以製造SDS·1/8水合物。在合併結晶製程中，255毫升的丙酮作為反溶劑加入結晶槽。此合併結晶製程的產率為83％，所生產出來的SDS經由傅里葉變換紅外光譜（FTIR）、熱重分析（TGA）、差示掃描量熱法(DSC)和粉末X射線衍射（PXRD）鑑定推測為SDS·1/8水合物。最後將生產出來的SDS·1/8水合物放置25、52、75%不同濕度之環境放置5天測試穩定度。經由穩定度測試下，生產出來的SDS·1/8水合物是很穩定的水合物型式

摘要(英)

Sodium dodecyl sulfate (SDS) was highly water soluble compound and was one of the commonly used surfactants. In previous studies, hydrate forms of SDS, 1/8 hydrate, hemihydrate, monohydrate, and anhydrous had been reported. However, there are few studies mentioned how to control the hydrate forms for SDS in the manufacturing process. Therefore, the aim of this thesis was to produce exact SDS·1/8 hydrate, through the combined process of evaporative, anti-solvent, cooling crystallization, and co-solvent system in batch system. First, purchased SDS crystals were immersed into the 1:17 volume ratio of co-solvent composed of water to acetone (v/v)) for preparation of SDS·1/8 hydrate. In combined process, 255mL of acetone was chosen as anit-solvent to introduce into crystallizer. Finally, produced SDS·1/8 hydrate was tested stability by exploring at 25, 52 and 75% relative humidity. The yield for the combined crystallization process was about 83%. The produced SDS was speculated to be SDS·1/8 hydrate, by characterization of Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). The result of stability test demonstrated that the produced SDS·1/8 hydrate was a stable form.

關鍵字(中)

★ 水合物
★ 共溶劑
★ 熟化

關鍵字(英)

★ hydrare
★ co-solvent
★ aging

論文目次

摘要.....................................................i
Abstract................................................ii
Acknowledgement.........................................iii
Table of Contents.......................................iv
List of Figures.........................................vii
List of Tables..........................................x
List of Schemes.........................................xi
Chapter 1 Introduction.................................1
1.1 Crystallization.................................1
1.1.1 Evaporative crystallization.....................1
1.1.2 Antisolvent Crystallization.....................2
1.1.3 Cooling Crystallization.........................3
1.2 Hydrates........................................4
1.3 Sodium Dodecyl Sulphate.........................5
1.4 Conceptual Framework............................13
1.5 References......................................14
Chapter 2 Experimental Materials and Methods...........17
2.1 Materials.......................................17
2.1.1 Chemicals.......................................17
2.1.2 Solvents........................................17
2.2 Experimental Methods............................19
2.2.1 Initial Solvent Screening.......................19
2.2.2 Combination of Composition Variation with Phase Diagram during Evaporation Process......................20
2.2.3 The End Point for Evaporation...................21
2.2.4 Preparation of SDS·1/8 Hydrate by Aging in Water /Acetone Co-solvent.....................................22
2.2.5 Crystallization Process of SDS·1/8 hydrate......23
2.2.6 Stability Test..................................27
2.3 Analytical Measurements.........................28
2.3.1 Optical Microscopy (OM).........................28
2.3.2 Fourier Transform Infrared Spectroscopy (FTIR)..28
2.3.3 Thermogravimetric Analysis (TGA)................29
2.3.4 Differential Scanning Calorimetry (DSC).........29
2.3.5 Powder X-ray Diffraction (PXRD).................30
2.3.6 References......................................31
Chapter 3 Results and Discussion.......................32
3.1 Use Test of SDS.................................32
3.2 Initial Solvent Screening of SDS................36
3.3 Composition Variations of SDS in Evaporative Crystallization Process 39
3.4 Determination of the End Point for Evaporation..42
3.5 Preparation of SDS·1/8 Hydrate by Aging in Water /Acetone Co-solvent.....................................45
3.6 Crystallization Process of SDS·1/8 Hydrate......49
3.7 Stability Test..................................57
3.8 References......................................60
Chapter 4 ........................................62
Conclusions and Future Works............................62
4.1 Conclusions.....................................62
4.2 Future Works....................................63

參考文獻

Khadka, P.; Ro, J.; Kim, H.; Kim, I.; Kim, J. T.; Kim, H.; Cho, J. M.; Yun, G.; Lee, J. Pharmaceutical Particle Technologies: An Approach to Improve Drug Solubility, Dissolution and Bioavailability. Asian J. Pharm. Sci. 2014, 9(6), 304-316.

Tung, H. H.; Paul, E. L.; Midler, M.; Mccauley, J. A. Crystallization of Organic Compounds: An Industrial Perspective; John Wiley & Sons, Inc.: New Jersey, 2009; pp 167-178.

Shariare, M., de Matas, M., and York, P. Effect of Crystallization Conditions and Feedstock Morphology on the Aerosolization Performance of Micronized Salbutamol Sulphate. Int. J. Pharm., 2011, 415(1), 62–72.

Hu, T. T.; Zhao, H.; Jiang, L. C.; Le, Y.; Chen J. F.; Yun, J. Engineering Pharmaceutical Fine Particles of Budesonide for Dry powder inhalation (DPI). Ind. Eng. Chem. Res., 2008, 47(23), 9623–9627

Tavare, N. Industrial Crystallization: Process Simulation, Analysis and Design; Plenum Publishing: New York, 1995; pp 1–564

Braun, D. E.; Griesser, U. J. Cryst. Stoichiometric and Nonstoichiometric Hydrates of Brucine, Cryst. Growth Des. 2016, 16(10), 6111−6121.

Vogt, F. G.; Brum, J.; Katrincic, L. M.; Flach, A.; Socha, J. M.; Goodman, R. M.; Haltiwanger, R. C. Physical, Crystallographic, and Spectroscopic Characterization of a Crystalline Pharmaceutical Hydrate: Understanding the Role of Water. Cryst. Growth Des. 2006, 6(10), 2333−2354.

Healy, A. M.; Worku, Z. A.; Kumar, D.; Madi, A. M. Pharmaceutical Solvates, Hydrates and Amorphous Forms: A Special Emphasis on Cocrystals. Adv Drug Deliv. Rev. 2017, 117, 25-46.

Hara, T. J.; Thompson, B. E. The Reaction of Whitefish, Coregonus Cupeaformis, to the Anionic Detergent Sodium Lauryl Sulphate and its Effects on their Olfactory Responses. Water Res. 1978, 12(10), 893-897.

Weber, K.; Osbron, M. The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J. Biol. Chem. 1969, 244 (16), 4406-4412.

Sundell, S. The Crystal Structure of Sodium Dodecyl Sulfate. Acta Chem. Scand. 1977, A31, 799–807.

Coiro, V. M.; Mazza, F.; Pochetti, G. Crystal Phases Obtained from Aqueous Solutions of Sodium Dodecyl Sulfate. The Structure of a Monoclinic Phase of Sodium Dodecyl Sulfate Hemihydrate. Acta Crystallogr. 1986, C42 (2), 991–995

Coiro, V. M.; Manigrasso, M.; Mazza, F.; Pochetti, G. Structure of a Triclinic Phase of Sodium Dodecyl Sulfate Monohydrate. A Comparison with Other Sodium Dodecyl Sulfate Crystal Phases. Acta Crystallogr. 1987, C43 (43), 850–854.

Smith, L. A.; Hammond, R. B.; Roberts, K. J.; Machin, D.; McLeod, G. Determination of the Crystal Structure of Anhydrous Sodium Dodecyl Sulphate using a Combination of Synchrotron Radiation Powder Diffraction and Molecular Modelling Techniques. J. Mol. Struct. 2000, 554 (2–3), 173–182.

Cal, K.; Sollohub K,. Spray drying technique. I: Hardware and process parameters. J. of Pharm. Sci., 2010, 99(2), 575-586

Prabhat K. Nema; Barjinder Pal Kaur; Arun S. Mujumdar. Spray dring. Drying Technologies for Foods: Fundamentals & Applications; New India Publishing Agency: New Delhi – India, 2015; pp 79-106

Lee, T.; Kuo, C.; Chen, Y. H. Solubility, Polymorphism, Crystallinity, and Crystal Habit of Acetaminophen and Ibuprofen by Initial Solvent Screening. Pharm. Technol. 2006, 30(10), 72-92.

Kékicheff, P. Phase Diagram of Sodium Dodecyl Sulfate-Water System. J. Colloid Interface Sci. 1989, 131(1), 133–152.

Kim, S.; Lotz, B.; Lindrud, M.; Girard, K.; Moore, T.; Nagarajan, K.; Alvarez, M.; Lee, T.; Nikfar, F.; Davidovich, M; Srivastava, S.; Kiang S. Control of the Particle Properties of a Drug Substance by Crystallization Engineering and the Effect on Drug Product Formulation. Org. Process Res. Dev. 2005, 9(6), 894–901.

Morris, K. R.; Fakes, M. G.; Thakur, A. B.; Newman, A. W.; Singh, A. K.; Venit, J. J.; Spagnuolo, C. J.; Serajuddin, A. T. M. An integrated approach to the selection of optimal salt form for a new drug candidate. Int. J. Pharm., 1994, 105(3), 209–217.

Wang, W.; Lu, H.; Liu, Y.; Leng, J. Sodium Dodecyl Sulfate/Epoxy Composite: Water-Induced Shape Memory Effect and Its Mechanism. J. Mater. Chem. A 2014, 2(15), 5441-5549.

Lee, T.; Kuo, C. S.; Chen, Y. H. Solubility, Polymorphism, Crystallinity, and Crystal Habit of Acetaminophen and Ibuprofen by Initial Solvent Screening. Pharm. Technol. 2006, 30 (10), 72-92.

Lichtfouse, E.; Schwarzbauer, J.; Robert, D. Pollutant Diseases, Remediation and Recycling, Springer: Switzerland, 2013; pp 277-320

Kékicheff, P. Phase Diagram of Sodium Dodecyl Sulfate-Water System. J. Colloid Interface Sci. 1989, 131 (1), 133–152.

Tung, H. H.; Paul, E. L.; Midler, M.; Mccauley, J. A. Crystallization of Organic Compounds: An Industrial Perspective; John Wiley & Sons, Inc.: New Jersey, 2009; pp 167-178.

Hoang, H.; Galliero, G. Shear Viscosity of Inhomogeneous Fluids. J. Chem. Phys. 2012, 136 (124902), 1-8.

Kékicheff, P. Phase Diagram of Sodium Dodecyl Sulfate-Water System. J. Colloid Interface Sci. 1989, 131(1), 133–152.

Smith, L. A.; Duncan, A.; Thomson, G. B.; Roberts, K. J.; Machin, D.; McLeod, G. Crystallization of Sodium dodecyl Sulphate from Aqueous Solution: Phase Identification, Crystal Morphology, Surface Chemistry and Kinetic Interface Roughening. J. Cryst. Growth. 2004, 263(1-4), 480-490.

指導教授

李度(Tu Lee)

審核日期

2019-7-25

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