利用不同造孔劑合成並分析具生物相容鈦鋯基金屬玻璃多孔醫用植入材

以作者查詢圖書館館藏

、以作者查詢臺灣博碩士

、以作者查詢全國書目

、勘誤回報

、線上人數：91

、訪客IP：3.16.29.209

姓名

阮帆泰(Van Tai Nguyen) 查詢紙本館藏

畢業系所

機械工程學系

論文名稱

利用不同造孔劑合成並分析具生物相容鈦鋯基金屬玻璃多孔醫用植入材
(Synthesis and characterization of biocompatible TiZr-based bulk metallic glass foam using different space holders for bio-implant applications)

相關論文

★ 鋯基與鋯銅基金屬玻璃薄膜應用於7075-T6航空用鋁合金疲勞性質提升之研究	★ 非晶質合金手術刀與非晶質合金鍍膜手術刀之銳利度研究
★ 以急冷旋鑄法及機械冶金法製備Zn4Sb3熱電塊材及其熱電性質之研究	★ 添加Ti顆粒對MgZnCa非晶質合金之機械性質研究
★ 不同製程對鋯基非晶質合金破裂韌性影響之研究	★ 硼碳元素對鐵基非晶質鋼材玻璃形成能力、熱性質及切削性質影響之研究
★ 鋯銅基塊狀金屬玻璃複材和鋯基塊狀金屬多孔材之製作及其性質分析之研究	★ 添加鉭顆粒與球狀鈦合金對鎂鋅鈣非晶質合金機械性質影響之研究
★ 高速火焰熔射製備鐵基非晶質合金塗層及其耐磨耗性與抗腐蝕性之研究	★ 不同製程對鋯-銅-鋁非晶質合金內析出ZrCu B2相分布及其機械性質影響之研究
★ 以塊狀金屬玻璃和其複材製作骨科鑽頭及其鑽孔能力之研究	★ 鋯基塊狀金屬玻璃與金屬玻璃鍍膜手術刀切削耐久度之研究
★ 利用急冷旋鑄及真空熱壓製備β-Zn4Sb3 奈米/微米晶塊材之熱電性質探討	★ 無鎳鋯基及鈦基金屬玻璃生物相容性之研究
★ 以鐵基金屬玻璃複材或金屬玻璃鍍膜製作手術用取皮刀並進行模擬切削性能之研究	★ 探討不同結晶率對鋯鋁鈷塊狀非晶質合金機械性質之影響

檔案

[Endnote RIS 格式]

[Bibtex 格式]

[相關文章]

[文章引用]

[完整記錄]

[館藏目錄]

至系統瀏覽論文 (2025-8-24以後開放)

摘要(中)

本次研究透過真空熱壓製程將無毒鈦鋯基金屬玻璃粉體以及造孔劑的混合物，成功製備一系列具生物相容性的多孔材，藉由調控氯化鈉以及鋁顆粒等兩種造孔劑的體積分率，設計出孔隙率介於2.0%到72.4%之間的熱壓鈦鋯基金屬玻璃多孔材。鈦鋯基金屬玻璃多孔材之形貌，其空孔孔徑落在75到300 m之間，與人體骨骼結構相似。首先，以X光繞射以及穿透式電子顯微鏡繞射進行分析，顯示鈦鋯基金屬玻璃粉體在經過熱壓製成多孔材之後依舊保持其非晶態。此外，我們可以成功藉由調整孔隙率達到調控楊氏系數的目的，當孔隙率從2.0%逐漸提高到72.4%時，鈦鋯基金屬玻璃多孔材的楊氏係數會從56.4 GPa降至2.3 GPa，抗壓強度從979 MPa降至19 MPa，彎曲強度從157 MPa降至49 MPa，使其更貼近人體骨骼。在生物相容性評估上，將2種造孔劑製備各孔隙率之鈦鋯金屬玻璃多孔材以並透過萃取法與直接接觸法進行細胞毒性和細胞外鈣沉積之測試，鈦鋯基金屬玻璃多孔材具備良好之生物相容性。使用萃取法測試孔隙率34.8％的多孔材在各稀釋溶液中，其細胞毒性和細胞外鈣沉積的平均細胞存活率和沈積率分別約為98.2％和224.4％。與此同時，使用直接接觸法測試孔隙率64.0％的多孔材在各稀釋溶液中，其細胞毒性和細胞外鈣沉積的平均細胞存活率和沈積率分別約為170.1％和130.9％。基於上述結果，鈦鋯基金屬玻璃多孔材應用在駐植物可藉由調控楊氏係數避免應力遮蔽效應，同時，優異的生物相容性表現可以視為生物植入材的明日之星。

摘要(英)

In this research, a series of biocompatible TiZr-based bulk metallic glass (BMG) foams (BMGFs) were successfully fabricated by hot pressing mixtures of toxic-element-free TiZr-based amorphous alloy powder and space holders. TiZr-based BMG samples with porosities ranging from 2.0% to 72.4% were designed by controlling the volume fractions of two space holders, namely NaCl and Al particles. The BMGFs fabricated using the aforementioned space holders exhibited pore sizes ranging from 75 to 300 m, which are similar to the pore sizes of human bones. X-ray diffraction patterns and transmission electron microscopy images revealed that the TiZr-based BMGFs remained the amorphous state after hot pressing. Moreover, when the porosity of the fabricated TiZr-based BMGFs was gradually increased from 2.0% to 72.4%, considerable reductions were observed in their Young’s modulus (from 56.4 to 2.3 GPa), compressive strength (from 979 to 19 MPa), and bending strength (from 157 to 49 MPa). The biocompatibility, namely noncytotoxicity and extracellular calcium deposition, of the TiZr-based BMGFs fabricated using NaCl and Al particles as the space holder was examined at various porosities by using the extract exposure and direct contact methods, respectively. The TiZr-based BMGFs exhibited high biocompatibility when both methods were performed. The BMGF with a porosity of 34.8%, which was tested in various diluted precipitate media by using the extract exposure method, exhibited an average cell survival of approximately 98.2% and a calcium deposition rate of approximately 224.4%. The BMGF with a porosity of 64.0%, which was tested using the direct contact method, exhibited an average cell survival rate of approximately 170.1% and a calcium deposition rate of approximately 130.9%. According to the aforementioned results, TiZr-based BMGFs have potential in bioimplants for the prevention of stress shielding and biounfriendly symptoms in the human body.

關鍵字(中)

★ 熱壓
★ 無定形材料
★ 生物材料
★ 機械性能
★ 多孔材料
★ 大塊金屬玻璃泡沫

關鍵字(英)

★ Hot-pressing
★ Amorphous materials
★ Biomaterials
★ Mechanical property
★ Porous materials
★ Bulk metallic glass foam

論文目次

摘要 i
Abstract ii
Acknowledgements iv
Contents v
List of Tables viii
List of Figures ix
Explanation of Symbols xiv
Chapter 1. INTRODUCTION 1
1-1 Development of TiZr-based Bulk Metallic Glass (BMG) 1
1-2 Challenges for TiZr-based BMGs 2
1-2-1 Glass-Forming Ability (GFA) 2
1-2-2 Biocompatibility 4
1-2-3 Mechanical Properties 5
1-3 Motivation and Goals 5
Chapter 2. LITERATURE REVIEWS 9
2-1 Characteristics of human bones 9
2-2 Designing Chemical Compositions of TiZr-based Bulk Metallic Glass (BMG) 11
2-3 Generating TiZr-based Metallic Glass (MG) powder 15
2-4 Fabricating TiZr-based Bulk Metallic Glass Foam (BMGF) 15
2-4-1 Space holder method 16
2-4-2 Replication method 17
2-4-3 Bubble generation 18
2-4-4 Freeze casting 20
2-4-5 Rapid prototyping 21
2-4-6 Conversion of porous ceramic precursor to metallic Ti foam 23
Chapter 3. EXPERIMENTAL DETAILS 25
3-1 Materials 25
3-1-1 Apparatus and Chemicals 25
3-1-2 Instrument 26
3-2 Experimental methods 28
3-2-1 Sample fabrication 28
3-2-2 Thermal stability analysis 30
3-2-3 Real Porosity 30
3-2-4 Microstructure characterization 31
3-2-5 Morphology 32
3-2-6 Mechanical property 32
3-2-7 Biocompatibility Tests 33
Chapter 4. RESULTS AND DISCUSSION 37
4-1 Thermal stability 37
4-2 Effects of conditional parameters on fabricating TiZr-based BMGF 39
4-3 Space holder removal 41
4-4 Real porosity 43
4-5 Morphology of TiZr-based BMGF 44
4-6 Structural characterization 46
4-7 Mechanical property 48
4-7-1 Young’s modulus, compressive strength and bending strength of TiZr-based BMFs 48
4-7-2 Predicting Young’s modulus and compressive strength by Gibson and Ashby model 50
4-8 Biocompatibility in vitro electrochemical testing 52
4-8-1 Extract exposure method 52
4-8-2 Direct contact method 54
Chapter 5. CONCLUSIONS 56
REFERENCES 58
Tables 68
Figures 81

參考文獻

[1] A. Inoue, A. Kato, T. Zhang, and T. Masumoto, "Mg–Cu–Y amorphous alloys with high mechanical strengths produced by a metallic mold casting method," Materials transactions, JIM, vol. 32, no. 7, pp. 609-616, 1991.
[2] A. Peker and W. L. Johnson, "A highly processable metallic glass: Zr41. 2Ti13. 8Cu12. 5Ni10. 0Be22. 5," Applied Physics Letters, vol. 63, no. 17, pp. 2342-2344, 1993.
[3] J. K. Lee, S. H. Kim, S.-H. Yi, W. T. Kim, and D.-H. Kim, "A study on the development of Ni-based alloys with wide supercooled liquid region," Materials Transactions, vol. 42, no. 4, pp. 592-596, 2001.
[4] H. Chen, "Thermodynamic considerations on the formation and stability of metallic glasses," Acta Metallurgica, vol. 22, no. 12, pp. 1505-1511, 1974.
[5] N. Nishiyama, K. Takenaka, H. Miura, N. Saidoh, Y. Zeng, and A. Inoue, "The world′s biggest glassy alloy ever made," Intermetallics, vol. 30, pp. 19-24, 2012.
[6] T. Li, P. Wong, S. Chang, P. Tsai, J. Jang, and J. Huang, "Biocompatibility study on Ni-free Ti-based and Zr-based bulk metallic glasses," Materials Science and Engineering: C, vol. 75, pp. 1-6, 2017.
[7] B. Huang, H. Bai, and W. Wang, "Unique properties of CuZrAl bulk metallic glasses induced by microalloying," Journal of Applied Physics, vol. 110, no. 12, p. 123522, 2011.
[8] P. C. Wong et al., "Enhanced mechanical properties of MgZnCa bulk metallic glass composites with Ti-particle dispersion," Metals, vol. 6, no. 5, p. 116, 2016.
[9] S. Pang, T. Zhang, K. Asami, and A. Inoue, "Synthesis of Fe–Cr–Mo–C–B–P bulk metallic glasses with high corrosion resistance," Acta Materialia, vol. 50, no. 3, pp. 489-497, 2002.
[10] Z. Yuqiao, N. Nishiyama, and A. Inoue, "Formation of a Ni-based glassy alloy in centimeter scale," Materials transactions, vol. 48, no. 6, pp. 1355-1358, 2007.
[11] I. Milošev, "CoCrMo alloy for biomedical applications," in Biomedical Applications: Springer, 2012, pp. 1-72.
[12] B. Basu, D. S. Katti, and A. Kumar, Advanced biomaterials: fundamentals, processing, and applications. John Wiley & Sons, 2010.
[13] M. A.-H. Gepreel and M. Niinomi, "Biocompatibility of Ti-alloys for long-term implantation," Journal of the mechanical behavior of biomedical materials, vol. 20, pp. 407-415, 2013.
[14] M. Long and H. Rack, "Titanium alloys in total joint replacement—a materials science perspective," Biomaterials, vol. 19, no. 18, pp. 1621-1639, 1998.
[15] M. Niinomi, Metals for biomedical devices. Elsevier, 2010.
[16] J. Z. Jiang, D. Hofmann, D. J. Jarvis, and H. J. Fecht, "Low‐Density High‐Strength Bulk Metallic Glasses and Their Composites: A Review," Advanced Engineering Materials, vol. 17, no. 6, pp. 761-780, 2015.
[17] W.-H. Wang, C. Dong, and C. Shek, "Bulk metallic glasses," Materials Science and Engineering: R: Reports, vol. 44, no. 2-3, pp. 45-89, 2004.
[18] K.-F. Xie, K.-F. Yao, and T.-Y. Huang, "A Ti-based bulk glassy alloy with high strength and good glass forming ability," Intermetallics, vol. 18, no. 10, pp. 1837-1841, 2010.
[19] M. Morrison, R. Buchanan, A. Peker, P. K. Liaw, and J. Horton, "Electrochemical behavior of a Ti-based bulk metallic glass," Journal of non-crystalline solids, vol. 353, no. 22-23, pp. 2115-2124, 2007.
[20] Y. Kim, D. Bae, W. Kim, and D. Kim, "Glass forming ability and crystallization behavior of Ti-based amorphous alloys with high specific strength," Journal of non-crystalline solids, vol. 325, no. 1-3, pp. 242-250, 2003.
[21] G. Xie, F. Qin, S. Zhu, and A. Inoue, "Ni-free Ti-based bulk metallic glass with potential for biomedical applications produced by spark plasma sintering," Intermetallics, vol. 29, pp. 99-103, 2012.
[22] M. Calin et al., "Designing biocompatible Ti-based metallic glasses for implant applications," Materials Science and Engineering: C, vol. 33, no. 2, pp. 875-883, 2013.
[23] C. Huang et al., "Electrochemical and biocompatibility response of newly developed TiZr-based metallic glasses," Materials Science and Engineering: C, vol. 43, pp. 343-349, 2014.
[24] T. Imwinkelried, "Mechanical properties of open‐pore titanium foam," Journal of biomedical materials research Part A, vol. 81, no. 4, pp. 964-970, 2007.
[25] A. Inoue and A. Takeuchi, "Recent development and application products of bulk glassy alloys," Acta Materialia, vol. 59, no. 6, pp. 2243-2267, 2011.
[26] P. Gong, L. Deng, J. Jin, S. Wang, X. Wang, and K. Yao, "Review on the research and development of Ti-based bulk metallic glasses," Metals, vol. 6, no. 11, p. 264, 2016.
[27] Y. Liu, G. Wang, H. Li, S. Pang, K. Chen, and T. Zhang, "TiCuZrFeSnSiSc bulk metallic glasses with good mechanical properties for biomedical applications," Journal of Alloys and Compounds, vol. 679, pp. 341-349, 2016.
[28] J.-J. Oak and A. Inoue, "Attempt to develop Ti-based amorphous alloys for biomaterials," Materials Science and Engineering: A, vol. 449, pp. 220-224, 2007.
[29] W. M. Elshahawy, I. Watanabe, and P. Kramer, "In vitro cytotoxicity evaluation of elemental ions released from different prosthodontic materials," Dental materials, vol. 25, no. 12, pp. 1551-1555, 2009.
[30] M. Niinomi, "Recent metallic materials for biomedical applications," Metallurgical and materials transactions A, vol. 33, no. 3, p. 477, 2002.
[31] C. Lin, C. Huang, J. Chuang, J. Huang, J. Jang, and C. Chen, "Rapid screening of potential metallic glasses for biomedical applications," Materials Science and Engineering: C, vol. 33, no. 8, pp. 4520-4526, 2013.
[32] C. Huang, J. Lai, J. Huang, C. Lin, and J. Jang, "Effects of Cu content on electrochemical response in Ti-based metallic glasses under simulated body fluid," Materials Science and Engineering: C, vol. 62, pp. 368-376, 2016.
[33] H. Cameron, I. Macnab, and R. Pilliar, "A porous metal system for joint replacement surgery," The International journal of artificial organs, vol. 1, no. 2, pp. 104-109, 1978.
[34] M. Geetha, A. K. Singh, R. Asokamani, and A. K. Gogia, "Ti based biomaterials, the ultimate choice for orthopaedic implants–a review," Progress in materials science, vol. 54, no. 3, pp. 397-425, 2009.
[35] W. C. Head, D. J. Bauk, and J. R. Emerson, "Titanium as the material of choice for cementless femoral components in total hip arthroplasty," Clinical orthopaedics and related research, no. 311, pp. 85-90, 1995.
[36] P. K. Zysset, X. E. Guo, C. E. Hoffler, K. E. Moore, and S. A. Goldstein, "Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur," Journal of biomechanics, vol. 32, no. 10, pp. 1005-1012, 1999.
[37] J. D. Currey, "What determines the bending strength of compact bone?," Journal of Experimental Biology, vol. 202, no. 18, pp. 2495-2503, 1999.
[38] H. Li and Y. Zheng, "Recent advances in bulk metallic glasses for biomedical applications," Acta biomaterialia, vol. 36, pp. 1-20, 2016.
[39] S. Kujala, J. Ryhänen, A. Danilov, and J. Tuukkanen, "Effect of porosity on the osteointegration and bone ingrowth of a weight-bearing nickel–titanium bone graft substitute," Biomaterials, vol. 24, no. 25, pp. 4691-4697, 2003.
[40] S. Chen et al., "Microstructure and mechanical properties of open-cell porous Ti-6Al-4V fabricated by selective laser melting," Journal of Alloys and Compounds, vol. 713, pp. 248-254, 2017.
[41] M. D. Demetriou et al., "Amorphous metals for hard-tissue prosthesis," Jom, vol. 62, no. 2, pp. 83-91, 2010.
[42] S. Guo et al., "A plastic Ni-free Zr-based bulk metallic glass with high specific strength and good corrosion properties in simulated body fluid," Materials letters, vol. 84, pp. 81-84, 2012.
[43] J. Li, H. Lin, J. Jang, C. Kuo, and J. Huang, "Novel open-cell bulk metallic glass foams with promising characteristics," Materials Letters, vol. 105, pp. 140-143, 2013.
[44] M. Nicoara, A. Raduta, R. Parthiban, C. Locovei, J. Eckert, and M. Stoica, "Low Young’s modulus Ti-based porous bulk glassy alloy without cytotoxic elements," Acta Biomaterialia, no. 36, pp. 323-331, 2016.
[45] J. Parthasarathy, B. Starly, S. Raman, and A. Christensen, "Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM)," Journal of the mechanical behavior of biomedical materials, vol. 3, no. 3, pp. 249-259, 2010.
[46] J. Schroers, G. Kumar, T. M. Hodges, S. Chan, and T. R. Kyriakides, "Bulk metallic glasses for biomedical applications," Jom, vol. 61, no. 9, pp. 21-29, 2009.
[47] G. Xie, F. Qin, S. Zhu, and D. Louzguine-Lugzin, "Corrosion behaviour of porous Ni-free Ti-based bulk metallic glass produced by spark plasma sintering in Hanks′ solution," Intermetallics, vol. 44, pp. 55-59, 2014.
[48] V. Nguyen et al., "Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application," Materials Letters, vol. 256, p. 126650, 2019.
[49] T. Li et al., "New method for determination of hidden supercooled liquid region of TiZr-based amorphous alloys," Journal of Non-Crystalline Solids, vol. 510, pp. 1-5, 2019.
[50] R. B. Martin, "Porosity and specific surface of bone," Critical reviews in biomedical engineering, vol. 10, no. 3, pp. 179-222, 1984.
[51] X. Wang and Q. Ni, "Determination of cortical bone porosity and pore size distribution using a low field pulsed NMR approach," Journal of Orthopaedic Research, vol. 21, no. 2, pp. 312-319, 2003.
[52] D. R. CARTER and D. M. Spengler, "Mechanical properties and composition of cortical bone," Clinical Orthopaedics and Related Research (1976-2007), vol. 135, pp. 192-217, 1978.
[53] F. G. Evans, Mechanical properties of bone. Thomas Springfield: , 1973.
[54] M. B. Schaffler and D. B. Burr, "Stiffness of compact bone: effects of porosity and density," Journal of biomechanics, vol. 21, no. 1, pp. 13-16, 1988.
[55] E. D. Sedlin, "A rheologic model for cortical bone: a study of the physical properties of human femoral samples," Acta Orthopaedica Scandinavica, vol. 36, no. sup83, pp. 1-77, 1965.
[56] M. Kutz, Biomedical engineering and design handbook. New York: McGraw-Hill, 2009.
[57] K. Hunt, V. D. O′Loughlin, D. Fitting, and L. Adler, "Ultrasonic determination of the elastic modulus of human cortical bone," Medical and biological engineering and computing, vol. 36, no. 1, pp. 51-56, 1998.
[58] A. H. Burstein, D. T. Reilly, and M. Martens, "Aging of bone tissue: mechanical properties," The Journal of bone and joint surgery. American volume, vol. 58, no. 1, pp. 82-86, 1976.
[59] T. Keller, Z. Mao, and D. Spengler, "Young′s modulus, bending strength, and tissue physical properties of human compact bone," Journal of Orthopaedic Research, vol. 8, no. 4, pp. 592-603, 1990.
[60] M. Martens, R. Van Audekercke, P. De Meester, and J. Mulier, "Mechanical behaviour of femoral bones in bending loading," Journal of Biomechanics, vol. 19, no. 6, pp. 443-454, 1986.
[61] M. Tang et al., "TiZr-base bulk metallic glass with over 50 mm in diameter," Journal of Materials Science & Technology, vol. 26, no. 6, pp. 481-486, 2010.
[62] L. Zhang et al., "Compressive plastic metallic glasses with exceptional glass forming ability in the Ti–Zr–Cu–Fe–Be alloy system," Journal of Alloys and Compounds, vol. 638, pp. 349-355, 2015.
[63] S. Zhu, X. Wang, and A. Inoue, "Glass-forming ability and mechanical properties of Ti-based bulk glassy alloys with large diameters of up to 1 cm," Intermetallics, vol. 16, no. 8, pp. 1031-1035, 2008.
[64] C. Ma, H. Soejima, S. Ishihara, K. Amiya, N. Nishiyama, and A. Inoue, "New Ti-based bulk glassy alloys with high glass-forming ability and superior mechanical properties," Materials transactions, vol. 45, no. 11, pp. 3223-3227, 2004.
[65] Y. Huang, J. Shen, J. Sun, and X. Yu, "A new Ti–Zr–Hf–Cu–Ni–Si–Sn bulk amorphous alloy with high glass-forming ability," Journal of Alloys and Compounds, vol. 427, no. 1-2, pp. 171-175, 2007.
[66] Y. Wang, H. Li, Y. Cheng, Y. Zheng, and L. Ruan, "In vitro and in vivo studies on Ti-based bulk metallic glass as potential dental implant material," Materials Science and Engineering: C, vol. 33, no. 6, pp. 3489-3497, 2013.
[67] R. Kokubun et al., "In vivo evaluation of a Ti-based bulk metallic glass alloy bar," Bio-medical materials and engineering, vol. 26, no. 1-2, pp. 9-17, 2015.
[68] Y. Hao et al., "Aging response of the Young’s modulus and mechanical properties of Ti-29Nb-13Ta-4.6 Zr for biomedical applications," Metallurgical and Materials Transactions A, vol. 34, no. 4, pp. 1007-1012, 2003.
[69] N. Sakaguchi, M. Niinomi, T. Akahori, J. Takeda, and H. Toda, "Relationships between tensile deformation behavior and microstructure in Ti–Nb–Ta–Zr system alloys," Materials Science and Engineering: C, vol. 25, no. 3, pp. 363-369, 2005.
[70] H. Wang et al., "Effect of cobalt microalloying on the glass forming ability of Ti–Cu–Pd–Zr metallic glass," Journal of non-crystalline solids, vol. 379, pp. 155-160, 2013.
[71] I. Catelas, J. D. Bobyn, J. B. Medley, J. J. Krygier, D. J. Zukor, and O. L. Huk, "Size, shape, and composition of wear particles from metal–metal hip simulator testing: effects of alloy and number of loading cycles," Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, vol. 67, no. 1, pp. 312-327, 2003.
[72] B. Pérez-Maceda et al., "Osteoblasts MC3T3-E1 response in 2D and 3D cell cultures models to high carbon content CoCr alloy particles. Effect of metallic particles on vimentin expression," 2017.
[73] M. Huber, G. Reinisch, G. Trettenhahn, K. Zweymüller, and F. Lintner, "Presence of corrosion products and hypersensitivity-associated reactions in periprosthetic tissue after aseptic loosening of total hip replacements with metal bearing surfaces," Acta Biomaterialia, vol. 5, no. 1, pp. 172-180, 2009.
[74] Y. Liao et al., "Synthesis and characterization of an open-pore toxic-element-free Ti-based bulk metallic glass foam for bio-implant application," Journal of Materials Research and Technology, 2020.
[75] R. Singh, P. Lee, R. Dashwood, and T. Lindley, "Titanium foams for biomedical applications: a review," Materials Technology, vol. 25, no. 3-4, pp. 127-136, 2010.
[76] M. Nicoara, A. Raduta, R. Parthiban, C. Locovei, J. Eckert, and M. Stoica, "Low Young’s modulus Ti-based porous bulk glassy alloy without cytotoxic elements," Acta biomaterialia, vol. 36, pp. 323-331, 2016.
[77] M. Bram, C. Stiller, H. P. Buchkremer, D. Stöver, and H. Baur, "High‐porosity titanium, stainless steel, and superalloy parts," Advanced engineering materials, vol. 2, no. 4, pp. 196-199, 2000.
[78] Z. Esen and Ş. Bor, "Processing of titanium foams using magnesium spacer particles," Scripta Materialia, vol. 56, no. 5, pp. 341-344, 2007.
[79] P. J. Kwok, S. M. Oppenheimer, and D. C. Dunand, "Porous titanium by electro‐chemical dissolution of steel space‐holders," Advanced engineering materials, vol. 10, no. 9, pp. 820-825, 2008.
[80] P. Kasten, I. Beyen, P. Niemeyer, R. Luginbühl, M. Bohner, and W. Richter, "Porosity and pore size of β-tricalcium phosphate scaffold can influence protein production and osteogenic differentiation of human mesenchymal stem cells: an in vitro and in vivo study," Acta biomaterialia, vol. 4, no. 6, pp. 1904-1915, 2008.
[81] E. Tsuruga, H. Takita, H. Itoh, Y. Wakisaka, and Y. Kuboki, "Pore size of porous hydroxyapatite as the cell-substratum controls BMP-induced osteogenesis," The Journal of Biochemistry, vol. 121, no. 2, pp. 317-324, 1997.
[82] S. R. Frenkel, W. L. Jaffe, F. Dimaano, K. Iesaka, and T. Hua, "Bone response to a novel highly porous surface in a canine implantable chamber," Journal of Biomedical Materials Research Part B: Applied Biomaterials: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, vol. 71, no. 2, pp. 387-391, 2004.
[83] B. Levine, "A new era in porous metals: applications in orthopaedics," Advanced Engineering Materials, vol. 10, no. 9, pp. 788-792, 2008.
[84] M. W. Kearns, P. Blenkinsop, A. Barber, and T. Farthing, "Manufacture of a novel porous metal," International journal of powder metallurgy (1986), vol. 24, no. 1, pp. 59-64, 1988.
[85] Y. Higuchi, Y. Ohashi, and H. Nakajima, "Biocompatibility of Lotus‐type Stainless Steel and Titanium in Alveolar Bone," Advanced Engineering Materials, vol. 8, no. 9, pp. 907-912, 2006.
[86] Z. Guo, C. Jee, N. Özgüven, and J. Evans, "Novel polymer–metal based method for open cell metal foams production," Materials Science and technology, vol. 16, no. 7-8, pp. 776-780, 2000.
[87] S. Thelen, F. Barthelat, and L. C. Brinson, "Mechanics considerations for microporous titanium as an orthopedic implant material," Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, vol. 69, no. 4, pp. 601-610, 2004.
[88] N. Davis, J. Teisen, C. Schuh, and D. C. Dunand, "Solid-state foaming of titanium by superplastic expansion of argon-filled pores," Journal of Materials Research, vol. 16, no. 5, pp. 1508-1519, 2001.
[89] E. D. Spoerke, N. G. Murray, H. Li, L. C. Brinson, D. C. Dunand, and S. I. Stupp, "A bioactive titanium foam scaffold for bone repair," Acta Biomaterialia, vol. 1, no. 5, pp. 523-533, 2005.
[90] V. I. Shapovalov, "Method for manufacturing porous articles," ed: Google Patents, 1993.
[91] C. Jee, Z. Guo, J. Evans, and N. Özgüven, "Preparation of high porosity metal foams," Metallurgical and Materials Transactions B, vol. 31, no. 6, pp. 1345-1352, 2000.
[92] Y. Chino and D. C. Dunand, "Directionally freeze-cast titanium foam with aligned, elongated pores," Acta Materialia, vol. 56, no. 1, pp. 105-113, 2008.
[93] J. Fife, J. Li, D. C. Dunand, and P. W. Voorhees, "Morphological analysis of pores in directionally freeze-cast titanium foams," Journal of Materials Research, vol. 24, no. 1, pp. 117-124, 2009.
[94] S.-W. Yook, B.-H. Yoon, H.-E. Kim, Y.-H. Koh, and Y.-S. Kim, "Porous titanium (Ti) scaffolds by freezing TiH2/camphene slurries," Materials Letters, vol. 62, no. 30, pp. 4506-4508, 2008.
[95] G. Ryan, A. Pandit, and D. P. Apatsidis, "Fabrication methods of porous metals for use in orthopaedic applications," Biomaterials, vol. 27, no. 13, pp. 2651-2670, 2006.
[96] L. Mullen, R. C. Stamp, W. K. Brooks, E. Jones, and C. J. Sutcliffe, "Selective Laser Melting: A regular unit cell approach for the manufacture of porous, titanium, bone in‐growth constructs, suitable for orthopedic applications," Journal of Biomedical Materials Research Part B: Applied Biomaterials: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, vol. 89, no. 2, pp. 325-334, 2009.
[97] W. Xue, B. V. Krishna, A. Bandyopadhyay, and S. Bose, "Processing and biocompatibility evaluation of laser processed porous titanium," Acta biomaterialia, vol. 3, no. 6, pp. 1007-1018, 2007.
[98] D. A. Hollander et al., "Structural, mechanical and in vitro characterization of individually structured Ti–6Al–4V produced by direct laser forming," Biomaterials, vol. 27, no. 7, pp. 955-963, 2006.
[99] P. Heinl, A. Rottmair, C. Körner, and R. F. Singer, "Cellular titanium by selective electron beam melting," Advanced Engineering Materials, vol. 9, no. 5, pp. 360-364, 2007.
[100] B. V. Krishna, S. Bose, and A. Bandyopadhyay, "Low stiffness porous Ti structures for load-bearing implants," Acta biomaterialia, vol. 3, no. 6, pp. 997-1006, 2007.
[101] P. Heinl, C. Körner, and R. F. Singer, "Selective electron beam melting of cellular titanium: mechanical properties," Advanced Engineering Materials, vol. 10, no. 9, pp. 882-888, 2008.
[102] G. Davies and S. Zhen, "Metallic foams: their production, properties and applications," Journal of Materials science, vol. 18, no. 7, pp. 1899-1911, 1983.
[103] A. R. Studart, U. T. Gonzenbach, E. Tervoort, and L. J. Gauckler, "Processing routes to macroporous ceramics: a review," Journal of the American Ceramic Society, vol. 89, no. 6, pp. 1771-1789, 2006.
[104] R. L. Centeno-Sánchez, D. J. Fray, and G. Z. Chen, "Study on the reduction of highly porous TiO 2 precursors and thin TiO 2 layers by the FFC-Cambridge process," Journal of materials science, vol. 42, no. 17, pp. 7494-7501, 2007.
[105] J. S. Jang, C. Chang, Y. Huang, J. Huang, W. Chiang, and C. Liu, "Viscous flow and microforming of a Zr-base bulk metallic glass," Intermetallics, vol. 17, no. 4, pp. 200-204, 2009.
[106] J. Li et al., "Viscous flow and thermoplastic forming ability of a Zr-based bulk metallic glass composite with Ta dispersoids," Journal of Alloys and Compounds, vol. 536, pp. S165-S170, 2012.
[107] A. Standard, "C1161-13, 2013," Standard test method for flexural strength of advanced ceramics at ambient temperature," ASTM International, West Conshohocken, PA 19428-2959, USA, 2013," ed.
[108] N. Jha, D. Mondal, J. D. Majumdar, A. Badkul, A. Jha, and A. Khare, "Highly porous open cell Ti-foam using NaCl as temporary space holder through powder metallurgy route," Materials & Design, vol. 47, pp. 810-819, 2013.
[109] A. El-Denglawey, M. Makhlouf, and M. Dongol, "The effect of thickness on the structural and optical properties of nano Ge-Te-Cu films," Results in Physics, vol. 10, pp. 714-720, 2018.
[110] M. Dongol, A. El-Denglawey, A. Elhady, and M. Ebied, "Synthesis and the RDF fine structure of Ge0. 15Te0. 78Cu0. 07 bulk alloy," Optik-International Journal for Light and Electron Optics, vol. 127, no. 19, pp. 8186-8193, 2016.
[111] M. Kutz, Standard handbook of biomedical engineering and design. McGraw-Hill New York, 2003.
[112] M. F. Ashby, T. Evans, N. A. Fleck, J. Hutchinson, H. Wadley, and L. Gibson, Metal foams: a design guide. Elsevier, 2000.
[113] ISO-10993-5: biological evaluation of medical devices part 5: test for cytotoxicity: in vitro methods, I. O. f. Standardization, Arlington, VA: ANSI/AAMI, 1999.
[114] M. H. Lee and D. J. Sordelet, "Synthesis of bulk metallic glass foam by powder extrusion with a fugitive second phase," Applied physics letters, vol. 89, no. 2, p. 021921, 2006.
[115] G. Duan, A. Wiest, M. L. Lind, A. Kahl, and W. L. Johnson, "Lightweight Ti-based bulk metallic glasses excluding late transition metals," Scripta Materialia, vol. 58, no. 6, pp. 465-468, 2008.
[116] S. Zhu, X. Wang, F. Qin, and A. Inoue, "A new Ti-based bulk glassy alloy with potential for biomedical application," Materials Science and Engineering: A, vol. 459, no. 1-2, pp. 233-237, 2007.
[117] S. Zhu, X. Wang, F. Qin, and A. Inoue, "Glass-forming ability and thermal stability of Ti–Zr–Cu–Pd–Si bulk glassy alloys for biomedical applications," Materials transactions, vol. 48, no. 2, pp. 163-166, 2007.
[118] J. Park, G. Wang, S. Pauly, N. Mattern, D. H. Kim, and J. Eckert, "Ductile Ti-based bulk metallic glasses with high specific strength," Metallurgical and Materials Transactions A, vol. 42, no. 6, pp. 1456-1462, 2011.
[119] F. Guo, H.-J. Wang, S. J. Poon, and G. J. Shiflet, "Ductile titanium-based glassy alloy ingots," Applied Physics Letters, vol. 86, no. 9, p. 091907, 2005.
[120] P. Zioupos, C. W. Smith, and Y. H. An, "4 Factors Affecting Mechanical."
[121] E. D. Sedlin and C. Hirsch, "Factors affecting the determination of the physical properties of femoral cortical bone," Acta Orthopaedica Scandinavica, vol. 37, no. 1, pp. 29-48, 1966.
[122] B. S. Mather, "The symmetry of the mechanical properties of the human femur," Journal of Surgical Research, vol. 7, no. 5, pp. 222-225, 1967.
[123] B. S. MATHER, "Correlations between strength and other properties of long bones," Journal of Trauma and Acute Care Surgery, vol. 7, no. 5, pp. 633-638, 1967.
[124] B. S. Mather, "The effect of variation in specific gravity and ash content on the mechanical properties of human compact bone," Journal of biomechanics, vol. 1, no. 3, pp. 207-210, 1968.
[125] J. Currey and G. Butler, "The mechanical properties of bone tissue in children," The Journal of bone and joint surgery. American volume, vol. 57, no. 6, pp. 810-814, 1975.
[126] H. Schryver, "Bending properties of cortical bone of the horse," American journal of veterinary research, vol. 39, no. 1, pp. 25-28, 1978.
[127] J. D. Currey, "Effects of differences in mineralization on the mechanical properties of bone," Philosophical Transactions of the Royal Society of London. B, Biological Sciences, vol. 304, no. 1121, pp. 509-518, 1984.
[128] J. D. Currey, "The effect of porosity and mineral content on the Young′s modulus of elasticity of compact bone," Journal of biomechanics, vol. 21, no. 2, pp. 131-139, 1988.
[129] C. Wen, M. Mabuchi, Y. Yamada, K. Shimojima, Y. Chino, and T. Asahina, "Processing of biocompatible porous Ti and Mg," Scripta Materialia, vol. 45, no. 10, pp. 1147-1153, 2001.
[130] C. Wen, Y. Yamada, K. Shimojima, Y. Chino, T. Asahina, and M. Mabuchi, "Processing and mechanical properties of autogenous titanium implant materials," Journal of Materials Science: Materials in Medicine, vol. 13, no. 4, pp. 397-401, 2002.
[131] C. Wen, Y. Yamada, K. Shimojima, Y. Chino, H. Hosokawa, and M. Mabuchi, "Novel titanium foam for bone tissue engineering," Journal of materials research, vol. 17, no. 10, pp. 2633-2639, 2002.
[132] U. Müller, T. Imwinkelried, M. Horst, M. Sievers, and U. Graf-Hausner, "Do human osteoblasts grow into open-porous titanium," Eur Cell Mater, vol. 11, pp. 8-15, 2006.
[133] B. Otsuki, M. Takemoto, S. Fujibayashi, M. Neo, T. Kokubo, and T. Nakamura, "Pore throat size and connectivity determine bone and tissue ingrowth into porous implants: three-dimensional micro-CT based structural analyses of porous bioactive titanium implants," Biomaterials, vol. 27, no. 35, pp. 5892-5900, 2006.
[134] C. Li and Z. Zhu, "Dynamic Young′s modulus of open-porosity titanium measured by the electromagnetic acoustic resonance method," Journal of Porous materials, vol. 13, no. 1, pp. 21-26, 2006.
[135] K. Zhu, C. Li, Z. Zhu, and C. Liu, "Measurement of the dynamic Young’s modulus of porous titanium and Ti6Al4V," Journal of materials science, vol. 42, no. 17, pp. 7348-7353, 2007.
[136] H. Müllner et al., "Acoustical and poromechanical characterisation of titanium scaffolds for biomedical applications," Strain, vol. 44, no. 2, pp. 153-163, 2008.
[137] M. Thieme et al., "Titanium powder sintering for preparation of a porous functionally graded material destined for orthopaedic implants," Journal of materials science: materials in medicine, vol. 12, no. 3, pp. 225-231, 2001.
[138] I.-H. Oh, N. Nomura, N. Masahashi, and S. Hanada, "Mechanical properties of porous titanium compacts prepared by powder sintering," Scripta Materialia, vol. 49, no. 12, pp. 1197-1202, 2003.
[139] Y. An et al., "Mechanical properties of environmental-electro-discharge-sintered porous Ti implants," Materials letters, vol. 59, no. 17, pp. 2178-2182, 2005.
[140] H.-D. Jung, S.-W. Yook, H.-E. Kim, and Y.-H. Koh, "Fabrication of titanium scaffolds with porosity and pore size gradients by sequential freeze casting," Materials letters, vol. 17, no. 63, pp. 1545-1547, 2009.
[141] M. Kutz, "Bone mechanics," Standard handbook of biomedical engineering and design, New York: McGraw-Hill, pp. 8.1-8.23, 2003.

指導教授

鄭憲清(Jason Jang Shian-Ching)

審核日期

2020-7-23

推文