高分子微流體晶片快速打樣製造之實踐

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姓名

蔡長軒(TSAI,CHANG-HSUAN) 查詢紙本館藏

畢業系所

機械工程學系

論文名稱

高分子微流體晶片快速打樣製造之實踐
(Practice of rapid proofing and manufacturing of polymer microfluidic chips)

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至系統瀏覽論文 (2025-8-21以後開放)

摘要(中)

本論文以便攜式手指驅動微型泵與閥，期望達成漸進式與簡易化之微型混合器微流體系統。微型混合器系統中流道設計和驅動力相關聯，除了手指驅動式以外微型混合皆須使用到外加機械、電磁和磁力的條件下控制泵與閥，再加上流道必須受限於固定型態設計才能完成，這會降低便攜性及耗費高成本。
為了使便攜式微型混合器操作容易且製程簡單好上手，並可在短時間內製作出來，本論文套用了智慧製造加工方法的選用概念以及簡易實驗室的理念，在製程上簡易的製造實驗室為無塵室製程提供了許多替代方案，低成本的製造設備，如CNC雕刻機、雷射切割機、3D列印機，使用市售的材料進行加工，並善加利用網路平台上共享資源與設計，相互討論與開發新型微流裝置的材料、工具與建構方法，激發個人創造力和創新。
研究利用智慧製造加工方法的概念將製程標準化，以達到簡易實驗室的理念，驗證方式從製程的最前端模具開始製作，三種不同材料性質的模具，黃銅、PMMA(聚甲基丙烯酸甲酯)與矽晶圓模具，接著中段微流道製作方法，探討了幾種常用低成本之設備，後則是尾端簡單快速的接合方法，接著透過三種商業與學術合作案例來進行驗證說明，再則我們將上述所提及的簡單製程概念進一步延伸，製作出一種手持便攜式混合裝置，其裝置內包含手指驅動微型泵與閥的集成；本文最後進行了漸進式混合效果之設計與測試。

摘要(英)

This thesis proposes to use portable hand-operated microfluidic devices Micropumps and valves, hoping to achieve a progressive and simplified micromixer microfluidic system. Channel design and driving force are related in the micromixer system. In addition to the hand-operated type, micromixer requires the use of applied mechanical, electromagnetic and magnetic forces to control pumps and valves, and the flow channel must be limited to a fixed form design to complete, which will reduce portability and increase cost.
In order to make the portable micromixer easy to operate, simple to use, and can be produced in a short time, this thesis applies the concept of intelligent manufacturing and processing methods and the idea of simple laboratory. In the process, the simple manufacturing laboratory provides many alternatives for the clean room process, low-cost manufacturing equipment, such as CNC engraving machines, laser cutting machines, and 3D printers. Using commercially available materials for processing, sharing resources and design on the network platform, we tried to discuss and develop the materials, tools and construction methods of new microfluidic devices to stimulate personal creativity and innovation.
This research uses the concept of smart manufacturing methods to standardize the process to achieve the concept of a simple laboratory. The verification method starts with the production of the front-end molds of the process, with three different material properties: brass, PMMA (polymethyl methacrylate) and silicon wafer molds. Then it discusses several common low cost equipments in the production of middle microchannel. After that, there is a simple and fast joining method at the end, and then through three commercial and academic cooperation cases to verify and explain it. What’s more, it further extends the above-mentioned simple process concept to produce a handheld portable micromixer device, with the integration of portable microfluidic devices micropumps and valves. Finally, at the end of this thesis, the design and testing of progressive mixing effects are carried out.

關鍵字(中)

★ 高分子材料
★ 微流體

關鍵字(英)

論文目次

目錄
摘要 I
Abstract II
誌謝 IV
目錄 VI
一、前言 1
1-1 微流體系統發展與應用 1
1-2 微流體系統之微型閥 3
1. 電動微閥(Electrokinetic Microvalves) 3
2. 磁力微閥(Magnetism Microvalves) 3
3. 氣動微閥(Pneumatic Microvalves) 4
1-3 微流體控制設備之即時檢測 4
1-3-1 自我操作微流體設備(Self-operated microfluidic devices) 6
1. 毛細管力(Capillary force) 6
2. 真空驅動壓力(Vacuum-driven pressure) 7
1-3-2 手動操作微流控制設備(Hand-operated microfluidic devices) 7
1. 注射器與微量分注器(Syringe pipette) 7
2. 手指驅動(Hand-operated microfluidic devices) 9
1-4 研究動機 14
二、實驗材料設備及方法 15
2-1 實驗材料 15
2-2 實驗設備 16
2-3 實驗方法 17
三、結果與討論 18
3-1 微流體製程聯網概念 18
3-1-1 模具 20
1. 矽晶圓模具 20
2. 金屬模具 21
3. 聚合物模具 22
3-1-2 流道製作 23
1. 熱壓印 23
2. CNC銑削 24
3. 3D列印 25
3-1-3 接合 26
1. 熱熔融接合 26
2. 表面處理接合 26
3. 膠帶接合 26
3-1-4 製程流程驗證 27
案例一. 微流體裝置成型液滴 27
案例二. 熱塑性材料快速接合(PC.PS) 29
案例三. 微流體裝置與生醫科技 30
3-2 手持式微流裝置設計 31
3-2-1 裝置作動原理 33
3-3 微流體系統閥門與泵 34
3-4 手持式混合裝置 37
四、結論與未來展望 41

參考文獻

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指導教授

曹嘉文(Tsao, Chia-Wen)

審核日期

2020-8-24

推文