摘要(英) |
Accurate localization of uterine fibroids from MRI images is crucial for High-Intensity Focused Ultrasound (HIFU) treatment. However, due to significant variations in the shape and size of uterine fibroids among individuals, low contrast with adjacent organs and tissues, and the unknown number of fibroids, it is challenging to precisely extract the position and size of uterine fibroids. Currently, the main approach relies on physicians spending time and using their experience to manually label the uterine fibroid regions in software.
To address this issue, we collaborated with Dr. Lin Gi-Gin′s team from Chang Gung Hospital and provided de-identified abdominal MRI images (IRB number: 202201307B0C502) to propose an image processing method. Firstly, four different combinations of image processing techniques were used to enhance the organ tissue contrast in the MRI images, resulting in four differentiated images. These images were then subjected to K-means clustering individually. Based on the characteristics of uterine fibroid images, we identified the clustering combination that includes the classification of uterine fibroids and other organ tissues as non-uterine fibroids. Finally, a series of post-processing steps including smoothing, noise removal, separation, and fibroid determination were applied to obtain the ultimate results. This method was compared to the traditional manual labeling of uterine fibroids by Dr. Lin Gi-Gin and the radiology team, and it was validated using 30 cases. |
參考文獻 |
[1]Mayo Clinic Explains Uterine Fibroids, https://www.youtube.com/watch?v=u3l3HMJmk_0
[2]長庚醫訊41卷9期P25-27子宮肌瘤的無創治療
[3]磁振造影專業基礎課程,中華民國醫事放射學會、國泰綜合醫院,民國105年6月19日
[4] 陳志宏、張允中、謝昭賢等, 核磁共振與磁振造影 (Nuclear Magnetic Resonanceand Magnetic Resonance Imaging)
[5] MICHAEL KASS, ANDREW WITKIN, and DEMETRI TERZOPOULOS Schlumberger Palo Alto Research, 3340 Hillview Ave., Palo Alto, CA 94304 ,” Snakes Active Contour Models”, 3340 Hillview Ave., Palo Alto, CA 94304 1987 KIuwer Academic Publishers, Boston, Manufactured in The Netherlands International Journal of Computer Vision, 321-331 (1988)
[6]直方圖均衡化 維基百科:https://zh.wikipedia.org/zh-tw/%E7%9B%B4%E6%96%B9%E5%9B%BE%E5%9D%87%E8%A1%A1%E5%8C%96
[7]圖像的點運算, https://www.shuangyi-tech.com/upload/20190921090133753873.pdf
[8] http://zhaoxuhui.top/blog/2018/11/03/ImageEntropy.html
[9] Ken Huang,影像雜訊去除 — 平滑法(Smoothing Method)https://medium.com/%E9%9B%BB%E8%85%A6%E8%A6%96%E8%A6%BA/%E5%BD%B1%E5%83%8F%E9%9B%9C%E8%A8%8A%E5%8E%BB%E9%99%A4-%E5%B9%B3%E6%BB%91%E6%B3%95-smoothing-method-53ebf2b99570
[10] k-平均演算法 維基百科https://en.wikipedia.org/wiki/K-means_clustering
[11]影像處理的形態學(Morphology)應用
https://medium.com/%E9%9B%BB%E8%85%A6%E8%A6%96%E8%A6%BA/%E5%BD%A2%E6%85%8B%E5%AD%B8-morphology-%E6%87%89%E7%94%A8-3a3c03b33e2b
[12] C. Phromlikhit, F. Cheevasuvit, and S. Yimman, "Tablet counting machine base on image processing," in Biomedical Engineering International Conference (BMEiCON), 2012. IEEE, 2012, pp. 1–5.
[13] Connected-component labeling ,維基百科:https://en.wikipedia.org/wiki/Connected-component_labeling
[14]形態學,https://jason-chen-1992.weebly.com/home/-morphology
[15] Haralick, Robert M., and Linda G. Shapiro. Computer and Robot Vision. 1st ed. USA: Addison-Wesley Longman Publishing Co., Inc., 1992
[16] T. F. Chan, L. A. Vese, Active contours without edges. IEEE Transactions on Image Processing, Volume 10, 2001.
[17] V. Caselles, R. Kimmel, G. Sapiro, Geodesic active contours. International Journal of Computer Vision, Volume 22, 1997.
[18] R. T. Whitaker, A level-set approach to 3d reconstruction from range data. International Journal of Computer Vision, Volume 29, 1998.
[19] Gonzalez, R. C., R. E. Woods, and S. L. Eddins. Digital Image Processing Using MATLAB. New Jersey, Prentice Hall, 2003
[20] Arthur, David, and Sergei Vassilvitskii. “K-Means++: The Advantages of Careful Seeding.” In Proceedings of the Eighteenth Annual ACM-SIAM Symposium on Discrete Algorithms, 1027–35. SODA ’07. USA: Society for Industrial and Applied Mathematics, 2007.
[21] Soille, P., Morphological Image Analysis: Principles and Applications, Springer, 1999
[22] Boomgaard, Rein van den, and Richard van Balen. “Methods for Fast Morphological Image Transforms Using Bitmapped Binary Images.” CVGIP: Graphical Models and Image Processing 54, no. 3 (May 1, 1992): 252–58. https://doi.org/10.1016/1049-9652(92)90055-3. |