| 摘要(英) |
Recently, the H5N1 virus has increasingly impacted to human life. It because that there are more and more people get infected. If the genome of the influenza virus recombined with the gene segments from other types of influenza viruses and caused infection through human to human, there will be a serious disaster. Hemagglutinin (HA) is the surface glycoprotein, and it will bind to sialic acid on the host cell surface receptors. So, the combination of the HA and sialic acid is important for the influenza infecting human. In this study, we select 497 sequences of the HA protein from NCBI Influenza Resource database, and use decision tree to select the key amino acid which would influence the binding of HA to sialic acid in the HA protein sequences. At the end, we have found 4 amino acid position at 54, 55, 241, and 281, those maybe important roles of the affection by H5N1 influenza virus. |
| 參考文獻 |
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