Using NF-κB as a molecular target for theranostics in radiation oncology research

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题名:	Using NF-κB as a molecular target for theranostics in radiation oncology research
作者:	許斐婷;Liu, Yu-Chang;Chiang, I-Tsang;Hsu, Fei-Ting;Hwang, Jeng-Jong
贡献者:	生醫理工學院生命科學系
关键词:	Animals;Antineoplastic Agents - pharmacology;Antineoplastic Agents - therapeutic use;Benzenesulfonates - pharmacology;Benzenesulfonates - therapeutic use;chemoresistance;Combined Modality Therapy;Drug Resistance, Neoplasm;Humans;IKK inhibitor;Molecular Targeted Therapy;molecular targeting;nanoparticle;Neoplasms - diagnosis;Neoplasms - drug therapy;Neoplasms - metabolism;Neoplasms - radiotherapy;NF-kappa B - antagonists & inhibitors;NF-kappa B - genetics;NF-kappa B - metabolism;NF-κB;Niacinamide - analogs & derivatives;Phenylurea Compounds;Prognosis;Pyridines - pharmacology;Pyridines - therapeutic use;Radiation Oncology;Radiation Tolerance - drug effects;radioresistance;Signal Transduction;sorafenib
日期:	2012-03-01
上传时间:	2026-04-23 11:14:17 (UTC+8)
出版者:	Taylor and Francis Ltd.;England: Taylor & Francis
摘要:	摘要： Resistance of cancer cells to chemotherapy and/or radiotherapy is a major challenge to current anticancer treatment. The NF-κB signaling pathway plays an important role in tumor development and progression, and results in unsatisfactory treatment outcome. Inhibition of the NF-κB signaling cascade may sensitize the resistant cancer cells to chemotherapy and/or radiotherapy. Here, the correlation of NF-κB molecules with carcinogenesis and tumor progression, along with its significance in clinical practice, is reviewed. The potential clinical application of NF-κB and its associated molecules as diagnostic and therapeutic targets is also discussed. 其他題名： Expert Rev Mol Diagn 出版者： England: Taylor & Francis 出版日期： 2012-03-01 出處： Expert review of molecular diagnostics, 2012-03, Vol.12 (2), p.139-146 版權： Expert Reviews Ltd 2012 識別號： ISSN: 1473-7159 識別號： ISSN: 1744-8352 識別號： EISSN: 1744-8352 識別號： DOI: 10.1586/erm.12.2 識別號： PMID: 22369374
显示于类别:	[生命科學系] 期刊論文

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