VDR and VDBP genes polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population

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题名:	VDR and VDBP genes polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population
作者:	高永旭;Lee, Shih-Wei;Chuang, Tzu-Yi;Huang, Hsiu-Han;Liu, Chi-Wei;Kao, Yung-Hsi;Wu, Lawrence Shih-Hsin
贡献者:	生醫理工學院生命科學系
关键词:	Female;Gene Frequency;Genetic Predisposition to Disease;Genotype;Humans;Infectious Disease;Macrophage Activation - genetics;Macrophage Activation - immunology;Macrophages - immunology;Male;Medical Education;Middle Aged;polymorphism;Polymorphism, Single Nucleotide - genetics;Receptors, Calcitriol - genetics;Taiwan;tuberculosis;Tuberculosis - genetics;VDBP;VDR;Vitamin D-Binding Protein - genetics
日期:	2016-10-01
上传时间:	2026-04-23 11:14:22 (UTC+8)
出版者:	Elsevier Taiwan LLC;England: Elsevier B.V
摘要:	摘要： The active metabolite (1, 25-dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to the activation of macrophages and the deficiency of vitamin D seems to be involved in the risk of tuberculosis (TB). The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. In this study, variation in the VDR and VDBP genes was investigated in a Taiwanese population with TB. We typed four VDR polymorphisms of restriction endonuclease sites for ApaI, TaqI, BsmI, and FokI and three VDBP polymorphisms—Thr420Lys, Asp416Glu, and Cys299Cys—in 198 patients with TB and 170 healthy volunteers. VDR TaqI, VDR BsmI, and VDBP Asp416Glu were significantly associated with TB susceptibility. Odd ratios of risk genotypes of the above three polymorphisms were 2.16 (95% confidence interval 1.01, 4.65), 2.14 (95% confidence interval 1.06, 4.31), and 2.24 (95% confidence interval 1.04, 4.80), respectively. VDBP haplotype analysis showed Gc1f carriers associated to TB. The polymorphisms in the VDR and VDBP genes appeared to be responsible for host susceptibility to human TB in a Taiwanese population. 其他題名： J Microbiol Immunol Infect 出版者： England: Elsevier B.V 出版日期： 2016-10-01 出處： Journal of microbiology, immunology and infection, 2016-10, Vol.49 (5), p.783-787 資源來源： Elsevier ScienceDirect Journals Complete 版權： 2016 版權： Copyright © 2016. Published by Elsevier B.V. 識別號： ISSN: 1684-1182 識別號： ISSN: 1995-9133 識別號： EISSN: 1995-9133 識別號： DOI: 10.1016/j.jmii.2015.12.008 識別號： PMID: 26869016
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