摘 要 生物反應器（bioreactor）為一種體外裝置，它可以提供適當的生化和機械刺激（如流體剪應力、拉伸、彎曲和壓縮等）的環境以促進細胞的生長及組織的變異。 本篇論文主要是在研究錐板型生物反應器內，流場剪應力的分佈情形。之前學者對於錐板型裝置的研究，均是考量圓錐是作單一方向性的旋轉。然而在真實的情況下，由於心臟的收縮與舒張會使得血液的流動為脈動（pulsatile）的形式，因此我們設定流場的流動為脈動式的。並且考慮此裝置具有邊界，研究邊界效應以及圓錐轉動頻率對於流場剪應力的影響。 Abstract Bioreactor is an in-vitro apparatus that can impart appropriate biochemical and mechanical environments to promote cell growth and tissue differentiation. Among the mechanical stimulation apparatus for the cell and tissue cultures, the cone-and-plate system has been applied to provide shear stresses for such as the endothelial and cartilage responses studies. Most of the previous studies considered the cone rotated steadily to generate steady-state shear stimulus. In this paper we consider the flow field is pulsatile. Contemplating two parameters which regard the shear stress, one is the side wall effects and the other is related to the frequency of the cone, we set up the formulation for the shear stress in the cone-and- plate system.
