This experimental study uses a wind tunnel and scale model to investigate turbulence effects on the discharge coefficient and mean flow rate of wind-driven cross-ventilation. The approaching flows include low turbulence smooth flow and grid-generated turbulent flow. Two different cross-ventilation configurations are considered in this study: (1) two opposite walls, each with one opening, and (2) two adjacent walls. each with one opening. The discharge coefficients of different flow conditions are determined by a fan technique. It is found that the discharge coefficient is a function of Reynolds number, wind incidence angle and direction of air flow (inhale or exhale), but independent of external turbulence intensity and wall porosity. However, because the leeward pressure is affected by external turbulence, the internal pressure and inlet velocity are dependent on external turbulence when the openings are on the opposite walls. The experimental results also verify that internal pressure and mean air flow rate can be predicted once the external pressure distribution and opening areas are known, regardless of whether the openings are on opposite walls or on adjacent walls. (C) 2009 Elsevier Ltd. All rights reserved.