Initial Salt Screening Procedures for Manufacturing Ibuprofen

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Title:	Initial Salt Screening Procedures for Manufacturing Ibuprofen
Authors:	Lee,T;Wang,YW
Contributors:	化學工程與材料工程學系
Keywords:	ACTIVE PHARMACEUTICAL INGREDIENT;SOLUBILITY;DRUG;SELECTION;CRYSTALLIZATION;DISSOLUTION;(S)-(+)-IBUPROFEN;CARBAMAZEPINE;DIFFRACTION;DIHYDRATE
Date:	2009
Issue Date:	2010-06-29 17:27:18 (UTC+8)
Publisher:	中央大學
Abstract:	The aim of this paper is to design initial salt screening procedures for manufacturing ibuprofen. Salt forms of a pharmaceutical acid racemic (R,S)-()-ibuprofen and their developable synthetic routes were ferreted out simultaneously through the screening of seven bases of sodium hydroxide, potassium hydroxide, l-arginine, l-histidine, l-lysine, diethanolamine, and tris(hydroxymethyl)aminomethane (THAM), and the match with the use of nine organic solvents of methanol, dimethyl sulfoxide, ethanol, N, N-dimethylformamide, acetonitrile, isopropyl alcohol, 1,4-dioxane, acetone, and tetrahydrofuran mainly in the presence of water in 20 mL scintillation vials. Racemic (R,S)-()-sodium ibuprofen dihydrate, a well-known ibuprofen salt and the newly discovered racemic (R,S)-()-THAM ibuprofen, appeared as white-squared powders with a molecular weight of 327.42 g/mol, a melting point of 160.17C, and the apparent solubility product, K'sp, of 6.0 10-4 M2 at 25C were successfully synthesized by the initial salt screening methods. The new amine salt of ibuprofen was monoclinic and had a space group of P21/c and lattice parameters of a = 17.578(8), b = 10.428(4), c = 9.991(4) , = 90.00, = 97.17(1), = 90.00, and V = 1,817.05(244) 3. The aspect ratio of the amine salt crystals of ibuprofen of 1.0 implied that the crystals had a better flowability than the sodium salt counterparts. This amine salt of ibuprofen was more stable in moist or dried atmospheres and was more hydrophobic than the sodium salt of ibuprofen. Moreover, the slow dissolution of this amine salt of ibuprofen might have made it less bitter and more suitable as a sustained release drug than the sodium salt of ibuprofen. The future work is to search for the different polymorphs of this amine salt of ibuprofen and to extend the initial salt screening working logics to the formation of co-crystals.
Relation:	DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Appears in Collections:	[National Central University Department of Chemical & Materials Engineering] journal & Dissertation

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