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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/26508


    Title: Entropy-driven binding/partition of amino acids dipeptides to stratum corneum lipid vesicles
    Authors: Lin,RY;Chen,WY;Liao,CW
    Contributors: 化學工程與材料工程學系
    Keywords: BINDING;PEPTIDE;SYSTEM;THERMODYNAMICS;PERMEABILITY;PARTITION;MEMBRANES;BILAYERS;PROTEIN;SKIN
    Date: 1998
    Issue Date: 2010-06-29 17:29:41 (UTC+8)
    Publisher: 中央大學
    Abstract: This study employed large unilamillar vesicles composed of purchased stratum corneum lipids to investigate the binding/partition of amino acids/dipeptides to stratum corneum lipid vesicles. The partition coefficients of amino acids/dipeptides between the stratum corneum lipid vesicles and the acetate buffer were determined by HPLC. In addition, the binding/partition enthalpy of amino acids/dipeptides with the stratum corneum lipid vesicles was derived by directly measuring the binding/partition heat with isothermal titration calorimetry. According to the binding/partition Gibbs free energy and the binding/partition enthalpy, all the binding/partition of amino acids/dipeptides with the stratum corneum lipid vesicles is endothermic, implying an entropy-driven binding/partition. Also, the equilibrium binding/partition results demonstrate that the partition coefficients of amino acids/dipeptides do not correlate with the transdermal permeability. This finding suggests that either the interaction between the penetrants and the lipid bilayer between corneocytes may not be a determining step or that the paracellular path is not a dominant route of transdermal penetration. (C) 1998 Elsevier Science B.V.
    Relation: JOURNAL OF CONTROLLED RELEASE
    Appears in Collections:[化學工程與材料工程研究所] 期刊論文

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