English  |  正體中文  |  简体中文  |  Items with full text/Total items : 67621/67621 (100%)
Visitors : 23093755      Online Users : 255
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/26510

    Title: Evaluation of a heterologous pericardium immobilized with heparin as a vascular patch in a canine model
    Authors: Chang,Y;Chen,CN;Sung,HW;Chiu,YT;Lu,JH
    Contributors: 化學工程與材料工程學系
    Date: 1998
    Issue Date: 2010-06-29 17:29:43 (UTC+8)
    Publisher: 中央大學
    Abstract: Heterologous pericardia, acquired from mammal, are often used as biological patches in cardiovascular surgery for pericardial substitute, intracardiac defect repair, stenosis enlargement, and change of blood stream direction. However, these biological patches have been clinically encountered with thrombus formation and tissue adhesion, These concerns may be overcome by immobilizing heparin on the surfaces of these biological patches. The study was to evaluate an epoxy-fixed porcine pericardium with ionically- or covalently-immobilized heparin implanted in a canine model as a vascular patch, The nonheparinized counterpart was used as a control, The results obtained suggested that surface-immobilized heparin may reduce thrombus formation and tissue adhesion of implanted biological patches. Additionally, the porcine pericardium with covalently-immobilized heparin was relatively better than its ionically-immobilized counterpart: in reducing thrombus formation and tissue adhesion. Therefore, it is suggested that heparin be immobilized by stable covalent bond in clinical use. The resistance against in vivo degradation for the heparinized tissues (ionically- or covalently-immobilized) was relatively better than the nonheparinized tissue. However, heparinization did not seem to prevent the implanted biological tissues from calcification.
    Appears in Collections:[化學工程與材料工程研究所] 期刊論文

    Files in This Item:

    File Description SizeFormat

    All items in NCUIR are protected by copyright, with all rights reserved.

    社群 sharing

    ::: Copyright National Central University. | 國立中央大學圖書館版權所有 | 收藏本站 | 設為首頁 | 最佳瀏覽畫面: 1024*768 | 建站日期:8-24-2009 :::
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback  - 隱私權政策聲明