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    題名: Preparation and release properties of biodegradable chitin microcapsules .1. Preparation of 6-mercaptopurine microcapsules by phase separation methods
    作者: Mi,FL;Tseng,YC;Chen,CT;Shyu,SS
    貢獻者: 化學工程與材料工程學系
    關鍵詞: POLYLACTIC ACID MICROSPHERES;GELATIN MICROSPHERES;EVALUATION INVITRO;ALPHA-CHITIN;DOXORUBICIN;BLEOMYCIN;INVIVO
    日期: 1997
    上傳時間: 2010-06-29 17:31:20 (UTC+8)
    出版者: 中央大學
    摘要: Chitin [poly-(N-acetyl-1,4-beta-D-glucopyranosamine)] microcapsules were prepared by the simple desolvation and the non-solvent addition phase separation methods. In the simple desolvation method, chitin droplets were dropped into the desolvation agent (water, ethanol, or acetone) and microcapsules soon formed. Several solvent-nonsolvent pairs: N,N-dimethylacetamide (DMAc)-water, DMAc-ethanol, DMAc-n-propanol, DMAc-n-butanol, and DMAc-acetone with different solubility parameter difference, (Delta delta) were chosen to prepare chitin microcapsules containing 6-mercaptopurine by using the nonsolvent-addition phase separation method. The results showed that the surface morphology and release behaviour of the microcapsules were greatly affected by different solvent-nonsolvent pairs. The surface of the microcapsules prepared from the system of high Delta delta was more smooth than those from the systems of low Delta delta. The drug content using the simple desolvation method increased with decreasing Delta delta because of the higher film formation rate of the microcapsules. On the other hand, the drug content using the nonsolvent addition method was lower than that using the simple desolvation method because of the dispersion forces, applied by mechanical stirring. Microcapsules prepared by the simple desolvation method had a narrower size distribution and larger mean size than those prepared by the nonsolvent addition method.
    關聯: JOURNAL OF MICROENCAPSULATION
    顯示於類別:[化學工程與材料工程研究所] 期刊論文

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