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    题名: Preparation and release properties of biodegradable chitin microcapsules .2. Sustained release of 6-mercaptopurine from chitin microcapsules
    作者: Mi,FL;Tseng,YC;Chen,CT;Shyu,SS
    贡献者: 化學工程與材料工程學系
    关键词: PARTIALLY DEACETYLATED CHITIN;CM-CHITIN;MICROSPHERES;CHITOSAN;BLEOMYCIN
    日期: 1997
    上传时间: 2010-06-29 17:31:22 (UTC+8)
    出版者: 中央大學
    摘要: Chitin microcapsules are prepared using a simple desolvation or nonsolvent addition phase separation method with 6-mercaptopurine (6-MP) as a reference core. Chitin with a molecular weight about 400 000 is used to prepare different core loaded microcapsules. The drug release rates of chitin microcapsules prepared by simple desolvation or nonsolvent addition method have different release profiles which are related to the rate of phase separation. With respect to the solubility parameter difference (Delta delta) value between solvent and nonsolvent, the release rate of 6-MP from microcapsules decreases with increasing Delta delta of the preparative system. The chitin beads show poor swelling properties and their release rates are pH-dependent. Sustained release of 6-MP from chitin microcapsules in low pH and neutral medium can be accomplished. To determine if the drug release from the polymer matrix is via a diffusion controlled or by an erosion controlled process, 6-MP release profiles of various chitin microcapsules degraded by lysozyme are investigated. The drug-release patterns of the chitin microcapsules prepared by nonsolvent addition (acetone, n-propanol, n-butanol) and simple desolvation in acetone are not only diffusion but also lysozyme digestion influenced. Whereas, by using water or ethanol as nonsolvent or desolvating agent, release profiles of the microcapsules prepared by nonsolvent addition and the simple desolvation method seem to be little affected by enzyme degradation. These results indicate that chitin might prove useful as a polymer carrier for the sustained release of drugs.
    關聯: JOURNAL OF MICROENCAPSULATION
    显示于类别:[化學工程與材料工程研究所] 期刊論文

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