The role of electroosmotic flow on in-vitro transdermal iontophoresis

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题名:	The role of electroosmotic flow on in-vitro transdermal iontophoresis
作者:	Lin,RY;Ou,YC;Chen,WY
贡献者:	化學工程與材料工程學系
关键词:	EXCISED HUMAN-SKIN;CONVECTIVE SOLVENT FLOW;TRANSPORT MECHANISMS;AMINO-ACIDS;MOUSE SKIN;WATER TRANSPORT;DELIVERY;MODEL;INVITRO;ENHANCEMENT
日期:	1997
上传时间:	2010-06-29 17:31:35 (UTC+8)
出版者:	中央大學
摘要:	Amino acids and their amino or carboxyl group blocked derivatives were selected to investigate the relative importance of the electroosmotic flow as comparing with the passive and electrical flows in transdermal iontophoresis. Specifically, the effects of the solute's hydrophobicity, the solute's charge, the buffer's salt concentration, and the electrical current density on the electroosmotic flow of transdermal were clearly demonstrated. In a summary, the electroosmotic flow direction enhanced the permeability of the positively charged solutes (anodic delivery), and the enhancements were diminished as the buffer's salt concentration increases; however, for anionic solutes and neutral solutes, the permeability reduced by increasing the buffer salt concentration was not as apparent as for cationic solutes since the negative effect of electroosmotic flow on anionic solutes was lessened as buffer concentration increases. Also, the increase in the electrical current density pushes up the permeability of cationic solutes by both increasing the electrical and electroosmotic flow; but for anionic solutes, the favor of the electrical flow in a higher electrical field was weakened by increasing negative electroosmotic flow. Furthermore, in the molecular weight range of the solutes under this investigation (89-300 g/mol), experimental results indicated that the hydrophobicity of solutes plays a more prominent role than molecular weight in passive diffusion, and the results allow to eliminate the argument of the permeability differences caused by the different molecular weights of the anionic solutes and the cationic solutes of this study.
關聯:	JOURNAL OF CONTROLLED RELEASE
显示于类别:	[化學工程與材料工程研究所] 期刊論文

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