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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/26587


    Title: A method to predict the transdermal permeability of amino acids and dipeptides through porcine skin
    Authors: Lin,RY;Hsu,CW;Chen,WY
    Contributors: 化學工程與材料工程學系
    Keywords: PENETRATION ENHANCEMENT;CONCENTRATION PROFILE;STRATUM-CORNEUM;DRUG DELIVERY;MODEL
    Date: 1996
    Issue Date: 2010-06-29 17:31:45 (UTC+8)
    Publisher: 中央大學
    Abstract: The penetration of various amino acids and dipeptides through porcine skin was measured in vitro in this work to examine the effect of lipophilicity and molecular weight of the compounds on the permeability of passive diffusion. Experimental results indicated that the effect of lipophilicity is a more dominant factor than the molecular weight. An equation was also developed to accurately predict the permeability of amino acids and dipeptides based on the lipophilicity of penetrants as follows: log K-p = -2.73 + 0.38ln K - 0.036(ln K)(2) with R(2) of 0.85 for the regression, where K, the lipophilicity, is represented by the partition coefficients of amino acids and dipeptides between the PEG/Na2SO4 aqueous two-phase system. In particular, the successful prediction of partition coefficients of dipeptides by Chen's method was used to further predict the dipeptides' permeability for transdermal delivery. The experimental results were deemed satisfactory.
    Relation: JOURNAL OF CONTROLLED RELEASE
    Appears in Collections:[化學工程與材料工程研究所] 期刊論文

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