EVALUATION OF THE PROPERTIES OF ETHYLCELLULOSE CELLULOSE TRIACETATE MICROCAPSULES CONTAINING THEOPHYLLINE PREPARED BY DIFFERENT MICROENCAPSULATION TECHNIQUES

NCUIR > Engineering College > National Central University Department of Chemical & Materials Engineering > journal & Dissertation > Item 987654321/26669

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/26669

Title:	EVALUATION OF THE PROPERTIES OF ETHYLCELLULOSE CELLULOSE TRIACETATE MICROCAPSULES CONTAINING THEOPHYLLINE PREPARED BY DIFFERENT MICROENCAPSULATION TECHNIQUES
Authors:	WU,JC;JEAN,WJ;CHEN,H
Contributors:	化學工程與材料工程學系
Keywords:	N/A
Date:	1994
Issue Date:	2010-06-29 17:33:48 (UTC+8)
Publisher:	中央大學
Abstract:	Using cellulose triacetate as an added complementary coating material in preparing sustained-release ethylcellulose-cellulose triacetate microcapsules of theophylline, three microencapsulation techniques were investigated. Ethylcellulose-cellulose triacetate composite microcapsules, ethylcellulose-cellulose triacetate dual-walled microcapsules and ethylcellulose microcapsules containing cellulose triacetate matrices were prepared using the non-solvent addition phase separation method. The effects of cellulose triacetate on the release of theophylline from the different ethylcellulose-cellulose triacetate microcapsules were obtained from dissolution studies. The results showed that the release rates of ethylcellulose-cellulose triacetate microcapsules were slower than those obtained from the ethylcellulose microcapsules prepared with similar core to wall ratios. The ethylcellulose microcapsules containing cellulose triacetate matrices had longer release half-times and smaller surface areas than the other capsule preparation. The release patterns of theophylline from the different ethylcellulose-cellulose triacetate microcapsules fitted first-order kinetics. Scanning electron micrographs showed that the surfaces of various ethylcellulose-cellulose triacetate microcapsules were different from those of theophylline, cellulose triacetate matrices of cellulose triacetate microcapsules, and that the surface morphology of ethylcellulose-cellulose triacetate microcapsules was affected by the preparative method.
Relation:	JOURNAL OF MICROENCAPSULATION
Appears in Collections:	[National Central University Department of Chemical & Materials Engineering] journal & Dissertation

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