DNA methylation profiles in monozygotic and dizygotic twins

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題名:	DNA methylation profiles in monozygotic and dizygotic twins
作者:	Kaminsky,ZA;Tang,T;Wang,SC;Ptak,C;Oh,GHT;Wong,AHC;Feldcamp,LA;Virtanen,C;Halfvarson,J;Tysk,C;McRae,AF;Visscher,PM;Montgomery,GW;Gottesman,II;Martin,NG;Petronis,A
貢獻者:	系統生物與生物資訊研究所
關鍵詞:	EPIGENETIC DIFFERENCES;GENE;DISCORDANT;DISEASE;GENOME;ASSOCIATION
日期:	2009
上傳時間:	2010-06-29 19:26:50 (UTC+8)
出版者:	中央大學
摘要:	Twin studies have provided the basis for genetic and epidemiological studies in human complex traits(1,2). As epigenetic factors can contribute to phenotypic outcomes, we conducted a DNA methylation analysis in white blood cells (WBC), buccal epithelial cells and gut biopsies of 114 monozygotic (MZ) twins as well as WBC and buccal epithelial cells of 80 dizygotic (DZ) twins using 12K CpG island microarrays(3,4). Here we provide the first annotation of epigenetic metastability of similar to 6,000 unique genomic regions in MZ twins. An intraclass correlation (ICC)-based comparison of matched MZ and DZ twins showed significantly higher epigenetic difference in buccal cells of DZ co-twins (P = 1.2 x 10(-294)). Although such higher epigenetic discordance in DZ twins can result from DNA sequence differences, our in silico SNP analyses and animal studies favor the hypothesis that it is due to epigenomic differences in the zygotes, suggesting that molecular mechanisms of heritability may not be limited to DNA sequence differences.
關聯:	NATURE GENETICS
顯示於類別:	[系統生物與生物資訊研究所] 期刊論文

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