English  |  正體中文  |  简体中文  |  Items with full text/Total items : 66984/66984 (100%)
Visitors : 23025945      Online Users : 305
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/27740


    Title: DNA methylation profiles in monozygotic and dizygotic twins
    Authors: Kaminsky,ZA;Tang,T;Wang,SC;Ptak,C;Oh,GHT;Wong,AHC;Feldcamp,LA;Virtanen,C;Halfvarson,J;Tysk,C;McRae,AF;Visscher,PM;Montgomery,GW;Gottesman,II;Martin,NG;Petronis,A
    Contributors: 系統生物與生物資訊研究所
    Keywords: EPIGENETIC DIFFERENCES;GENE;DISCORDANT;DISEASE;GENOME;ASSOCIATION
    Date: 2009
    Issue Date: 2010-06-29 19:26:50 (UTC+8)
    Publisher: 中央大學
    Abstract: Twin studies have provided the basis for genetic and epidemiological studies in human complex traits(1,2). As epigenetic factors can contribute to phenotypic outcomes, we conducted a DNA methylation analysis in white blood cells (WBC), buccal epithelial cells and gut biopsies of 114 monozygotic (MZ) twins as well as WBC and buccal epithelial cells of 80 dizygotic (DZ) twins using 12K CpG island microarrays(3,4). Here we provide the first annotation of epigenetic metastability of similar to 6,000 unique genomic regions in MZ twins. An intraclass correlation (ICC)-based comparison of matched MZ and DZ twins showed significantly higher epigenetic difference in buccal cells of DZ co-twins (P = 1.2 x 10(-294)). Although such higher epigenetic discordance in DZ twins can result from DNA sequence differences, our in silico SNP analyses and animal studies favor the hypothesis that it is due to epigenomic differences in the zygotes, suggesting that molecular mechanisms of heritability may not be limited to DNA sequence differences.
    Relation: NATURE GENETICS
    Appears in Collections:[系統生物與生物資訊研究所] 期刊論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML711View/Open


    All items in NCUIR are protected by copyright, with all rights reserved.

    社群 sharing

    ::: Copyright National Central University. | 國立中央大學圖書館版權所有 | 收藏本站 | 設為首頁 | 最佳瀏覽畫面: 1024*768 | 建站日期:8-24-2009 :::
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback  - 隱私權政策聲明