Determination of estrogenic compounds in wastewater using liquid chromatography-tandem mass spectrometry with electrospray and atmospheric pressure photoionization following desalting extraction

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题名:	Determination of estrogenic compounds in wastewater using liquid chromatography-tandem mass spectrometry with electrospray and atmospheric pressure photoionization following desalting extraction
作者:	Chen,HC;Kuo,HW;Ding,WH
贡献者:	中央大學
关键词:	ENDOCRINE-DISRUPTING COMPOUNDS;SOLID-PHASE EXTRACTION;TREATMENT-PLANT EFFLUENTS;ION SUPPRESSION;DRINKING-WATER;CHEMICAL-IONIZATION;STEROID ESTROGENS;NATURAL-WATERS;HUMAN PLASMA;FLOW-RATE
日期:	2009
上传时间:	2010-06-29 19:45:14 (UTC+8)
出版者:	化學研究所
摘要:	Two complementary LC-MS ionization methods, electrospray (ESI) and atmospheric pressure photoionization (APPI), have been optimized to determine three natural estrogenic compounds (estrone, 17 beta-estradiol and estriol) and two synthetic estrogenic compounds (17 alpha-ethynylestradiol and diethylstilbestrol) in the influent and effluent of wastewater treatment plants (WWTPs). The wastewater samples were first subjected to solid-phase extraction coupled with desalting extraction to remove matrix interference. The analytes were then detected using liquid chromatography-tandem mass spectrometry (LC-MS-MS) with ESI and dopant-assisted (DA) APPI to evaluate the ion suppression effect and to complement the detection and quantification of estrogenic compounds in complex wastewater samples. The average ion suppression factors for the extracts of the WWTP influent analyzed using ESI and APPI were 52 +/- 5% and 27 +/- 7%, respectively. The sensitivity and ionization efficiency of the LC-ESI-MS-MS system decreased dramatically when a complex matrix was present in the WWTP influent sample. Estrogenic compounds could be detected in the WWTP influent and effluent samples at concentrations below the parts-per-billion level. The lower detection limits obtained when using ESI and the higher matrix tolerance of the APPI method allowed the complete quantification of estrogenic Compounds in very complex samples in a complementary manner. (C) 2008 Elsevier Ltd. All rights reserved.
關聯:	CHEMOSPHERE
显示于类别:	[化學研究所] 期刊論文

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