本研究係以某大型學術研究機構為對象，透過問卷調查及內部安全衛生稽查資料分析方式，探討該組織導入管理資訊系統後，對化學物質運作之影響。探討內容包括歷年來化學物質安全管理之成效、化學物質之運作量，及有害事業廢棄物清運量之改變。分析項目為研究人員使用系統之動機、最常使用之管理功能等，並鑑別研究人員對系統重要性與滿意度認知之落差。 本研究發現：化學物質管理系統推行期間，化學物質庫存量有下降之趨勢。毒性化學物質之運作及物質安全資料表備置之合法性則有明顯改善。但可能受到研究對象組織改組，及實驗室搬遷等因素之影響，系統推行期間，與現場管理有關之化學物質安全管理績效並無明顯改變。系統推行期間，有害事業廢棄物委託清除處理量並未隨使用量之增加比例上升。 研究結果顯示，整體而言，研究人員非常認同化學物質管理系統之重要性，但對系統之滿意度則分別受系統使用之方便性，及系統使用動機等因素之影響而降低。 本研究係探討系統推行三年期間，相關管理情形之變化。其中有關化學物質使用量與事業廢棄物產量之關係，及作業現場安全管理之影響，後續需較長時間之觀察與研究，方可確認化學物質管理系統導入之效益。 The purpose of this research was to study the influence when a research institute introduced management information system on chemical substances management. This study applied questionnaires and the institutes' safety and health auditing documents. Analyze the effects of the performance of chemical safety management, and the quantities change about the handling chemical substances, and the hazardous waste during the past years. The items of analysis included the researchers' motives of using chemical management system, management function using frequently, and the factors that affect to use this system. Finally, the gap between the importance and satisfaction of perception about the chemical management system for the researchers were identified. This research finds that during the chemical management system promoted period, the inventory quantities of the chemical substance had a trend of decreasing year by year. The legitimacy of the toxicity chemistry managing, and preparation of material safety data sheet (MSDS) had obvious improved. The chemical safety management in laboratory has no obvious change, it may be influence by the institute reorganization, and the laboratories transferring. The amount of hazardous waste disposal had not rise with the increasing of chemical consumption. The results of study shown that generally, the researchers deeply identified with the importance of chemical management system. But the degree of the satisfaction decreases with convenience and the motives of using the system separately. The purpose of this research is to study related management changes during the three years promoting period. It will take more time to observe and research to ensure the relationship between chemical consumption and amount of hazard waste disposed, the influence of chemical safety management. On the benefit of chemical management system is more apparent.