Design of potent inhibitors for Schistosoma japonica glutathione S-transferase

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/34166

Title:	Design of potent inhibitors for Schistosoma japonica glutathione S-transferase
Authors:	Jao SC,Chen J,Yang K,Li WS.
Contributors:	化學研究所
Keywords:	ANTISCHISTOSOMAL DRUG PRAZIQUANTEL;BINDING-SITE;THERMODYNAMIC ANALYSIS;ETHACRYNIC-ACID;ACTIVE-SITE;RESISTANCE;MANSONI;TARGET;CYTOTOXICITY;OLTIPRAZ
Date:	2006
Issue Date:	2010-07-07 11:58:47 (UTC+8)
Publisher:	中央大學
Abstract:	We implemented both structure-based drug design and the concept of polyvalency to discover a series of potent and unsymmetrical Schistosoma japonicum glutathione S-transferase (SjGST) inhibitors 10-12. This strategy achieved not only an excellent enhancem
Relation:	BIOORGANIC & MEDICINAL CHEMISTRY
Appears in Collections:	[Graduate Institute of Chemistry] journal & Dissertation

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