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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/3948


    Title: 探討添加oxygen vector對Penicillium brevi-compactum在液態發酵中生產Mycophenolic acid及培養溫度對其在固態發酵鐘聲產產物之影響;Effects of Mycophenolic acid production by controlling oxygen supply on Penicillium brevicompactum and improvement by adding oxygen vectors on liquid state ferment
    Authors: 陳冠州;Guan-Zhou Chen
    Contributors: 化學工程與材料工程研究所
    Keywords: 通氣量;麥考酚酸;盤尼西林;固態發酵;oxygen vector;specific oxygen uptake rate;mycophenolic acid;penicillium brevi-compactum;aeration rate
    Date: 2006-07-05
    Issue Date: 2009-09-21 12:26:45 (UTC+8)
    Publisher: 國立中央大學圖書館
    Abstract: 本研究利用培養Penicillium brevi-compactum生產Mycophenolic acid(MPA),MPA用來作為器官移植時抑制免疫反應的藥物,作為Inositol MonoPhosphate DeHydrogenase(IMPDH)之非競爭型抑制劑。 ??研究中利用攪拌式發酵槽調整發酵期間之通氣量(0.05vvm、0.2vvm、0.4vvm、0.5vvm、1.0vvm、1.2vvm、1.5vvm),探討最佳的培養條件,最適合菌體生長的通氣量為1.5vvm,而對於菌體發酵生產MPA的產率來看,最適通氣量為1.0vvm。另外,由實驗結果發現通氣量=1.5vvm下的比生長速率(μ)最大,菌體生長所需要之時間最短,產物生產所需要的時間也最短。在添加oxygen vector的實驗中。藉由添加C14作為oxygen vector,在低通氣量中(0.05vvm)便可得到最佳MPA的產量,顯現添加oxygen vector,有利於Penicillium brevi-compactum生產MPA的製程。 ??b固態發酵的探討上,發現菌體生長和MPA產量方面,攝氏28度是最適合的。 Effects of oxygen supply on the production, MPA production and product yield by Penicillium brevicompactum were evaluated by four air flow rate-controlled batch cultures. As the air flow rate was controlled as 0.05, 0.4, 0.5 ,1.0vvm of each batch, the maximum MPA concentration increased from 0.210 to 0.236 g/liter, and product yield (Yp/s) increased form 0.017 to 0.026. By adding 2%C14 (1-tetradecene ) as oxygen vector in the low oxygen supply condition, the batch (0.05vvm) performed similar fermentation kinetic as that of the sufficient oxygen supply condition(1.0vvm). Lower energy consumption in aeration system could be obtain by adding C14 in the batch culture.
    Appears in Collections:[化學工程與材料工程研究所] 博碩士論文

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