本論文區分為兩大部份，第一部分研究醫療用個人氧氣製造機以分離空氣製造富氧氣的系統為模擬對象，針對協力廠商所設計的二升製氧機程序與提供的進料條件進行改善與發展。藉由本論文的研究成果預測最佳化的操作條件，及能達到的氧氣純度。由協力廠商提供設計雙塔六步驟程序，採用 OXYSIV-5XPTM 吸附劑，處理進料氣體為 78.3% 氮氣、20.762% 氧氣、0.938% 氬氣。在變動閥值調整為最佳化後，可達到之氧氣濃度為 92mol%，產量為 1.83L/min (STP) 平均產氣流率。 第二部分為研究酒精脫水之變壓力吸附程序，將低於共沸組成濃度 (95wt%) 的乙醇和水混合物利用變壓吸附法提高至無水酒精純度 98.7mol% (99.5wt%)。酒精脫水程序設計為比較 Skarstrom Vacuum 雙塔四步驟程序，加入低壓沖洗步驟成為雙塔六步驟程序，及再加上產氣加壓步驟為雙塔八步驟程序。四步驟程序無法達到無水酒精標準，六步驟程序因為適時犧牲一些回收率將有助於提高純度，但是也未能達標準。八步驟程序的乙醇濃度可達98.7mol%，乙醇回收率相對於六步驟程序也略為提升。接下來討論雙塔八步驟程序為絕熱系統與非恆溫系統的比較，發現兩者差異不大。所以本論文將採取雙塔八步驟程序、絕熱系統。最後本研究將探討各操作變數 (如：進料壓力、吸附塔塔長、抽真空壓力、高壓產氣時間、低壓沖洗時間) 對程序的影響。 This thesis studied two pressure swing adsorption (PSA) system including medical oxygen generation from air and production of anhydrous alcohol from bio-ethanol. Part I of the study was a two-bed six-step process of 2L oxygen concentrator with feed conditions provided by Merits Company to simulate oxygen product purity and average product flow rate. Simulation was performed for the bulk separation of N2/O2/Ar (78.3/20.762/0.938 vol. %) and the process utilized OXYSIV-5XPTM as adsorbent. The results showed that oxygen concentration achieved 92% or average product flow rate achieved 1.83L/min (STP) after varying valve value. Part II of the study was simulation of pressure swing adsorption in anhydrous alcohol (99.5wt%) production process from a flow of ethanol feed vapor (92wt%). This work developed three kinds of PSA process, i.e. the two-bed four-step process (Skarstrom Vacuum), the two-bed six-step process (including purge step), and the two-bed eight-step process (including backfill step). The simulation showed that two-bed eight-step process achieved 99.5wt% ethanol and a 96.2% recovery. Therefore, the study discussed with performance difference of two-bed eight-step PSA process between general non-isotherm system and adiabatic system. Finally, the optimal operating condition was obtained by varying the operating variables, such as feed pressure, adsorber length, vacuum pressure and step time.