高功能特性的固體具有製藥、電子、光學、催化、鐵電、氣體儲存、晶體架構的應用，往往可以藉由不同的物種進行分子組裝與辨認而量身訂造，且不需分子斷鍵或形成共價鍵。在超分子化學和晶體工程的結果產生二級（晶格）結構的尺度規模稱之為共晶。然而，儘管對於共晶有大量及廣泛的回顧、個案研究和溶解度的數學模型，大部分的研究仍主要集中在藥物活性成分（APIs）。因此，這三年研究計畫的目標，應採取充分利用這些現有進步的API 技術來創建其他一些奇特的超分子結構，而其結構可由非手性核酸鹼基的分子辨認將其引導之，例如，胞嘧啶與二元酸的加合物或氨基酸、精素或糖的加合物，其中二元酸之烷烴鏈長度從零發展到兩個碳原子。該系統的研究是為了更加深度了解蛋白質與核酸相互作用、基因調節控制、突變或致癌和藥物在分子尺度下的相互作用的基本形態，甚至是為新方法或新類型的光電材料準備而鋪路。 Supreme functional properties of solid forms with pharmaceutical, electronic, optical, catalytic, ferroelectric, gas storage, and crystal architectural applications can often be tailor-made by invoking molecular assembly and recognition event between different molecular species without the need to break or form covalent bonds of the molecules. This consequence of supramolecular chemistry and crystal engineering at the secondary (crystal lattice) structural length scale is called a co-crystal. However, despite of a large number of extensive reviews, case studies and mathematical solubility models for co-crystals, most of the studies have focused mainly on pharmaceutical active ingredients (APIs). Therefore, the aim of this 3-year research proposal is to take the full advantage of those current advancements in APIs to create some other exotic supramolecular architectures which are directed by the molecular recognition of an achiral nucleobase such as cytosine with adducts of dicarboxylic acids whose alkane chain lengths are increased from 0 to 2 carbons or with adducts of amino acids or with spermine or with sugars. The systematic studies may pave the way to more profound levels of understanding of the elementary patterns in protein-nucleic acid interactions, the process of gene regulation, mutation/carcinogenesis, drug action at the molecular level, and even new means to prepare novel types of optoelectronic materials. 研究期間：9908 ~ 10007
