本實驗室擬提出不對稱合成天然物 Squamocin-N and cis-Sylvaticin 之計畫。此兩個天然物皆屬於annonaceous acetogenin 類化合物。本合成的特色為化合物之雙四氫呋喃核心部分皆由具光學活性的1,5-正己雙烯-3,4-雙醇借由烯置換反應連結而得；並採用本實驗室研發之亞甲基縮醛作為繫繩以促進環閉合置換反應。 Asymmetric synthesis of natural products Squamocin-N and cis-Sylvaticin, both belonging to the family of annonaceous acetogeninsm, is proposed. The bis-THF cores of these natural products will be synthesized using (3R,4R)-, (3S,4S)-, (3R,4S)-1,5-hexadiene-3,4-diols (1 and 2) as the sole source of carbon atoms and stereocenters. The methylene acetal function is applied as a new linker/tether to facilitate the ring-closing metathesis. 研究期間：10008 ~ 10107
