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    题名: Hemocompatible Mixed-Charge Copolymer Brushes of Pseudozwitterionic Surfaces Resistant to Nonspecific Plasma Protein Fouling
    作者: Chang,Y;Shu,SH;Shih,YJ;Chu,CW;Ruaan,RC;Chen,WY
    贡献者: 化學工程與材料工程學系
    关键词: SELF-ASSEMBLED MONOLAYERS;TRANSFER RADICAL POLYMERIZATION;HUMAN SERUM-ALBUMIN;LOW PH;ADSORPTION;SULFOBETAINE;POLYMERS;TETRAGLYME;FIBRINOGEN;PROPERTY
    日期: 2010
    上传时间: 2012-03-27 16:25:07 (UTC+8)
    出版者: 國立中央大學
    摘要: In this work, the hemocompatibility of a sulfobetaine-like copolymer brush resulting from a mixed charge copolymerization of the positively charged 11-mercapto-N,N,N-trimethylammonium chloride (TMA) and negatively charged 11-mercaptoun-decylsulfonic acid (SA) was studied. Mixed charge distribution in the prepared poly(TMA-co-SA) copolymer brushes was controlled by the regulation of the reaction rate of the surface-initiated atom transfer radical polymerization (ATRP). The adsorption behavior of plasma proteins on a surface grafted with poly(TMA-co-SA) was measured by a surface plasmon resonance (SPR) sensor. The effects of varying temperature, solution pH, and ionic strength on the antifouling, characteristics of the mixed-charge copolymer brushes were systematically evaluated, and the protein-fouling resistance was discussed in detail, especially with respect to the effect of ionic strength on the intra- and intermolecular interactions of the poly(TMA-co-SA) with proteins. The adhesion and activation of blood cells on the poly(TMA-co-SA)-grafted surface contact with human whole blood was also demonstrated. The results suggest that mixed-charge copolymer brushes of poly(TMA-co-SA), which, like zwitterionic homopolymer brushes, have overall charge neutrality, can be used in similar applications for protein fouling resistance and have excellent hemocompatibility with human whole blood at physiologic temperatures.
    關聯: LANGMUIR
    显示于类别:[化學工程與材料工程學系 ] 期刊論文

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