Nonlinear Coupling in the Human Motor System

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题名:	Nonlinear Coupling in the Human Motor System
作者:	Chen,CC;Kilner,JM;Friston,KJ;Kiebel,SJ;Jolly,RK;Ward,NS
贡献者:	生物醫學工程研究所
关键词:	ELECTROCORTICOGRAPHIC SPECTRAL-ANALYSIS;HUMAN SENSORIMOTOR CORTEX;EVENT-RELATED COHERENCE;PARKINSONS-DISEASE;CORTICAL CONNECTIONS;OSCILLATORY ACTIVITY;HUMAN BRAIN;SYNCHRONIZATION;EEG;DESYNCHRONIZATION
日期:	2010
上传时间:	2012-03-27 16:25:14 (UTC+8)
出版者:	國立中央大學
摘要:	The synchronous discharge of neuronal assemblies is thought to facilitate communication between areas within distributed networks in the human brain. This oscillatory activity is especially interesting, given the pathological modulation of specific frequencies in diseases affecting the motor system. Many studies investigating oscillatory activity have focused on same frequency, or linear, coupling between areas of a network. In this study, our aim was to establish a functional architecture in the human motor system responsible for induced responses as measured in normal subjects with magnetoencephalography. Specifically, we looked for evidence for additional nonlinear (between-frequency) coupling among neuronal sources and, in particular, whether nonlinearities were found predominantly in connections within areas (intrinsic), between areas (extrinsic) or both. We modeled the event-related modulation of spectral responses during a simple hand-grip using dynamic casual modeling. We compared models with and without nonlinear connections under conditions of symmetric and asymmetric interhemispheric connectivity. Bayesian model comparison suggested that the task-dependent motor network was asymmetric during right hand movements. Furthermore, it revealed very strong evidence for nonlinear coupling between sources in this distributed network, but interactions among frequencies within a source appeared linear in nature. Our results provide empirical evidence for nonlinear coupling among distributed neuronal sources in the motor system and that these play an important role in modulating spectral responses under normal conditions.
關聯:	JOURNAL OF NEUROSCIENCE
显示于类别:	[生物醫學工程研究所 ] 期刊論文

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