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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/49918


    Title: A Guided Mode Resonance Aptasensor for Thrombin Detection
    Authors: Lin,SF;Ding,TJ;Liu,JT;Lee,CC;Yang,TH;Chen,WY;Chang,JY
    Contributors: 化學工程與材料工程學系
    Keywords: SINGLE-STRANDED-DNA;PROTEIN-DETECTION;APTAMER;BIOSENSOR;ASSAY;RNA;MOLECULES;SELECTION;LIGANDS;SURFACE
    Date: 2011
    Issue Date: 2012-03-27 16:26:27 (UTC+8)
    Publisher: 國立中央大學
    Abstract: Recent developments in aptamers have led to their widespread use in analytical and diagnostic applications, particularly for biosensing. Previous studies have combined aptamers as ligands with various sensors for numerous applications. However, merging the aptamer developments with guided mode resonance (GMR) devices has not been attempted. This study reports an aptasensor based home built GMR device. The 29-mer thrombin aptamer was immobilized on the surface of a GMR device as a recognizing ligand for thrombin detection. The sensitivity reported in this first trial study is 0.04 nm/mu M for thrombin detection in the concentration range from 0.25 to 1 mu M and the limit of detection (LOD) is 0.19 mu M. Furthermore, the binding affinity constant (K(a)) measured is in the range of 10(6) M(-1). The investigation has demonstrated that such a GMR aptasensor has the required sensitivity for the real time, label-free, in situ detection of thrombin and provides kinetic information related to the binding.
    Relation: SENSORS
    Appears in Collections:[化學工程與材料工程學系 ] 期刊論文

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