We report seismo-ionospheric precursors of anomalous decreases in the total electron content (TEC) appearing day 5 prior to an M9.3 earthquake, the largest one in the last five decades, which occurred in Sumatra-Andaman, Indonesia on 26 December 2004. Sequences of global ionosphere maps of the TEC derived from worldwide ground-based receivers of the global positioning system (GPS) are used to statistically study the temporal and spatial precursors of the earthquake. It was found that the temporal precursor of the GPS TEC around the epicenter was significantly reduced during the afternoon period on d 5 before the earthquake. The spatial precursors prominently, persistently, and simultaneously appear around the epicenter and its conjugate areas of the SumatraAndaman earthquake.