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| Title: | The relationship between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: a potential serum marker to evaluate cardiac autonomic control and sudden cardiac death |
| Authors: | Lin,YH;Lin,C;Lo,MT;Lin,HJ;Wu,YW;Hsu,RB;Chao,CL;Hsu,HC;Wang,PC;Wu,VC;Wang,SS;Lee,CM;Chien,KL;Ho,YL;Chen,MF;Peng,CK |
| Contributors: | 數據分析方法研究中心 |
| Keywords: | EXTRACELLULAR-MATRIX TURNOVER;AMINO-TERMINAL PROPEPTIDE;NONISCHEMIC DILATED CARDIOMYOPATHY;LEFT-VENTRICULAR DYSFUNCTION;MYOCARDIAL-INFARCTION;ALDOSTERONE BLOCKADE;PROGNOSTIC VALUE;SPIRONOLACTONE;ASSOCIATION;ECHOCARDIOGRAPHY |
| Date: | 2010 |
| Issue Date: | 2012-03-27 17:50:19 (UTC+8) |
| Publisher: | 國立中央大學 |
| Abstract: | Background: Cardiac extra-cellular matrix (ECM) fibrosis plays an important role in the pathophysiology of heart failure (HF). It may provide electrical heterogeneity and a substrate for arrhythmogenicity, which may cause sudden cardiac death (SCD). Methods: Twenty-one patients with manifestations of HF and a left ventricular ejection fraction (LVEF) <= 50% were enrolled. The median age was 62 years and median LVEF was 33%. Time-and frequency-domain analysis of heart rate variability (HRV) on 24 h ambulatory electrocardiography recording was assessed. Serum markers of ECM turnover including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) were analyzed. Results: The serum PIIINP concentration was correlated significantly with standard deviation of all normal to normal R-R intervals (SDNN) (r=-0.722, p=<0.001), percentage of adjacent NN interval differences >50 ms (pNN50) (r=-0.528, p=0.014), percentage of adjacent NN interval differences >20 ms (pNN20) (r=-0.545, p=0.002), very low frequency (VLF) (r=-0.490, p=0.024), low frequency (LF) (r=-0.491, p=0.024), and high frequency (HF) (r=-0.513, p=0.018). PINP, MMP-2, -9, TIMP-1 were not correlated with time-and frequency-domain analysis of HRV. Conclusions: PIIINP was significantly correlated with time- and frequency-domain analysis of HRV in HF patients. PIIINP is a potential serological marker to evaluate cardiac autonomic control and risk of SCD in HF patients. Clin Chem Lab Med 2010; 48:1821-7. |
| Relation: | CLINICAL CHEMISTRY AND LABORATORY MEDICINE |
| Appears in Collections: | [數據分析方法研究中心 ] 期刊論文
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