Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endothelium-denuded hypercholesterolaemic rabbits

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Title:	Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endothelium-denuded hypercholesterolaemic rabbits
Authors:	Yang,TL;Lin,FY;Chen,YH;Chiu,JJ;Shiao,MS;Tsai,CS;Ling,SJ;Chen,YL
Contributors:	生命科學系
Keywords:	SMOOTH-MUSCLE-CELLS;CHOLESTEROL-FED RABBITS;DEFICIENT MOUSE AORTA;IN-VITRO;TRANSCRIPTION FACTORS;CEREBRAL-ISCHEMIA;VASCULAR CELLS;RICH FRACTION;LDL OXIDATION;LIVER-INJURY
Date:	2011
Issue Date:	2012-03-27 18:11:20 (UTC+8)
Publisher:	國立中央大學
Abstract:	BACKGROUND: Atherosclerosis and restenosis are inflammatory responses involving free radicals and lipid peroxidation and may be prevented/cured by antioxidant-mediated lipid peroxidation inhibition. Salvianolic acid (Sal B), a water-soluble antioxidant obtained from a Chinese medicinal herb, is believed to have multiple preventive and therapeutic effects against human vascular diseases. In this study the in vitro and in vivo inhibitory effects of Sal B on oxidative stress were determined. RESULTS: In human aortic endothelial cells (HAECs), Sal B reduced oxidative stress, inhibited low-density lipoprotein (LDL) oxidation and reduced oxidised LDL-induced cytotoxicity. Sal B inhibited Cu(2+)-induced LDL oxidation in vitro (with a potency 16.3 times that of probucol) and attenuated HAEC-mediated LDL oxidation as well as reactive oxygen species (ROS) production. In cholesterol-fed New Zealand White rabbits (with probucol as positive control), Sal B intake reduced Cu(2+)-induced LDL oxidation, lipid deposition in the thoracic aorta, intimal thickness of the aortic arch and thoracic aorta and neointimal formation in the abdominal aorta. CONCLUSION: The data obtained in this study suggest that Sal B protects HAECs from oxidative injury-mediated cell death via inhibition of ROS production. The antioxidant activity of Sal B may help explain its efficacy in the treatment of vascular diseases. (C) 2010 Society of Chemical Industry
Relation:	JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
Appears in Collections:	[Department of Life Science] journal & Dissertation

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