Serotonin Receptor 5-HT(2B) Mediates Serotonin-Induced Mechanical Hyperalgesia

NCU Institutional Repository > 生醫理工學院 > 生命科學系 > 期刊論文 > Item 987654321/50848

請使用永久網址來引用或連結此文件: http://ir.lib.ncu.edu.tw/handle/987654321/50848

題名:	Serotonin Receptor 5-HT(2B) Mediates Serotonin-Induced Mechanical Hyperalgesia
作者:	Lin,SY;Chang,WJ;Lin,CS;Huang,CY;Wang,HF;Sun,WH
貢獻者:	生命科學系
關鍵詞:	DORSAL-ROOT GANGLION;FORMALIN-INDUCED NOCICEPTION;INFLAMMATORY MEDIATORS;PAIN;RAT;ACTIVATION;SENSITIZATION;SUBTYPE;MICE;5-HYDROXYTRYPTAMINE
日期:	2011
上傳時間:	2012-03-27 18:11:23 (UTC+8)
出版者:	國立中央大學
摘要:	Serotonin [5-hydroxytryptamine (5-HT)] released from mast cells or platelets in peripheral tissues is one of the important inflammatory mediators in pain and hyperalgesia. The involvement of 5-HT in pain is complex because it could inhibit or facilitate nociceptive transmission, reflecting the presence of multiple 5-HT subtype receptors on peripheral and central nociceptors. The present study aimed to investigate the involvement of 5-HT(2B) in 5-HT-induced pain and whether the subtype exists in dorsal root ganglion (DRG) neurons. Injecting the 5-HT or 5-HT(2) agonist in hindpaws of mice induced significant hyperalgesia to mechanical stimuli, which was inhibited by the 5-HT(2B/2C) antagonist but not by 5-HT(1A), 5-HT(2A), or 5-HT(3A) antagonists. Therefore, 5-HT(2B) or 5-HT(2C) may be involved in 5-HT-induced mechanical hyperalgesia. The 5-HT(2B/2C) antagonist also blocked 5-HT-induced transient [Ca(2+)] signaling in DRG neurons. All subtypes of 5-HT receptors except 5-HT(2C) and 5-HT(6) are present in DRGs. In situ hybridization also demonstrated 5-HT(2B) mainly expressed in small-to medium-diameter DRG neurons that respond to pain. Likely, 5-HT(2B) mediates 5-HT-induced mechanical hyperalgesia in mice.
關聯:	JOURNAL OF NEUROSCIENCE
顯示於類別:	[生命科學系] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	690	檢視/開啟

在NCUIR中所有的資料項目都受到原著作權保護.

社群 sharing

資料載入中.....