DEVELOPMENT OF NEW SULFUR-CONTAINING CONJUGATED COMPOUNDS AS ANTI-HCV AGENTS

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题名:	DEVELOPMENT OF NEW SULFUR-CONTAINING CONJUGATED COMPOUNDS AS ANTI-HCV AGENTS
作者:	Hwu,JR;Lin,SY;Tsay,SC;Singha,R;Pal,BK;Leyssen,P;Neyts,J
贡献者:	化學學系
关键词:	HEPATITIS-C-VIRUS;IN-VITRO;REPLICATION;DERIVATIVES;INHIBITORS;POTENT;GUANOSINE
日期:	2011
上传时间:	2012-03-27 18:11:53 (UTC+8)
出版者:	國立中央大學
摘要:	Various conjugated compounds containing a coumarin moiety and a heterocyclic nucleus were synthesized. Their activity against hepatitis C virus was tested on subgenomic replicon replication in Huh 5-2 cells. Some heterobicycle-coumarin conjugates with the -S-CH(2)-linker were found to possess appealing antiviral activities. The sulfur atom in these conjugated compounds was found to be an essential element to their antiviral activity.
關聯:	PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
显示于类别:	[化學學系] 期刊論文

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