Design and Control of a Ferromagnetic Coded Micro-Carrier Biochip Sensor for Multiplex Detection of Antibodies

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题名:	Design and Control of a Ferromagnetic Coded Micro-Carrier Biochip Sensor for Multiplex Detection of Antibodies
作者:	Chang,RS;Tsai,JZ;Li,TY
贡献者:	光電科學與工程學系
关键词:	MAGNETOPHORETIC MICROSYSTEM;GALECTIN-1
日期:	2011
上传时间:	2012-03-27 18:15:43 (UTC+8)
出版者:	國立中央大學
摘要:	This paper describes a method for producing a novel type of ferromagnetic coded micro-carrier. The ferromagnetic coded micro-carriers are about 200 mu m in length, 200 mu m in width and 50 mu m in thickness, and contain eight code elements with two distinguishable codes (hollow and solid), allowing for 2(8) unique codes. The code shapes include rectangle, circle, etc. Differently shaped coded micro-carriers could carry different antigens for detection of its complementary antibody. These many shapes of coded micro-carriers would be used simultaneously allowing us to make multiple detections for different antibodies at the same time. A molding process is applied for fabrication of the ferromagnetically coded micro-carriers where Fe material (Fe powder mixed with binder) is shaped in many tiny molds to produce the coded shapes used for identification of the bio-molecules. Magnetic force is used to control the movement and location of the ferromagnetic coded micro-carriers to prevent the loss during the hybridization process. The results of image process and analysis system testing are satisfactory. The results of our micro-carrier detection system for two sets of R and B color analysis are proportional to those obtained from ELISA antibody detection.
關聯:	SENSORS
显示于类别:	[光電科學與工程學系] 期刊論文

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