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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/51870


    Title: Identification of the minimum effective dose based on weighted Kaplan-Meier statistics
    Authors: Chang,YM;Chen,YI
    Contributors: 統計研究所
    Keywords: CENSORED SURVIVAL-DATA;TESTING PROCEDURES;INFERENCE;TRIALS
    Date: 2011
    Issue Date: 2012-03-27 19:08:01 (UTC+8)
    Publisher: 國立中央大學
    Abstract: Testing procedures are considered for identifying the minimum effective dose (MED) in a dose-response study with randomly right-censored survival data, where the MED is defined to be the smallest dose level under study that has survival advantage over the zero dose control. The proposed testing procedures are implemented in a step-down manner together with three different types of weighted Kaplan-Meier statistics. Comparative results of a Monte Carlo error rate and power/bias study for a variety of survival and censoring distributions are then presented and discussed. The application of the proposed procedures is finally illustrated for identifying the MED of the diethylstilbestrol in the treatment of prostate cancer.
    Relation: JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION
    Appears in Collections:[統計研究所] 期刊論文

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