English  |  正體中文  |  简体中文  |  Items with full text/Total items : 70548/70548 (100%)
Visitors : 23171125      Online Users : 388
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/52992

    Title: Universal geometrical factor of protein conformations as a consequence of energy minimization
    Authors: Wu,MC;Li,MS;Ma,WJ;Kouza,M;Hu,CK
    Contributors: 物理學系
    Date: 2011
    Issue Date: 2012-06-11 10:53:15 (UTC+8)
    Publisher: 國立中央大學
    Abstract: The biological activity and functional specificity of proteins depend on their native three-dimensional structures determined by inter-and intra-molecular interactions. In this paper, we investigate the geometrical factor of protein conformation as a consequence of energy minimization in protein folding. Folding simulations of 10 polypeptides with chain length ranging from 183 to 548 residues manifest that the dimensionless ratio (V/A < r >) of the van der Waals volume V to the surface area A and average atomic radius < r > of the folded structures, calculated with atomic radii setting used in SMMP (Eisenmenger F. et al., Comput. Phys. Commun., 138 (2001) 192), approach 0.49 quickly during the course of energy minimization. A large scale analysis of protein structures shows that the ratio for real and well-designed proteins is universal and equal to 0.491 +/- 0.005. The fractional composition of hydrophobic and hydrophilic residues does not affect the ratio substantially. The ratio also holds for intrinsically disordered proteins, while it ceases to be universal for polypeptides with bad folding properties. Copyright (C) EPLA, 2011
    Relation: EPL
    Appears in Collections:[物理學系] 期刊論文

    Files in This Item:

    File Description SizeFormat

    All items in NCUIR are protected by copyright, with all rights reserved.

    社群 sharing

    ::: Copyright National Central University. | 國立中央大學圖書館版權所有 | 收藏本站 | 設為首頁 | 最佳瀏覽畫面: 1024*768 | 建站日期:8-24-2009 :::
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback  - 隱私權政策聲明