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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/53741


    Title: 兩性雙離子性共聚物之合成以抵抗聚丙烯膜表面之生物積垢;Amphiphilic and zwitterionic copolymer synthesis for anti-fouling surface coating on polypropylene membranes
    Authors: 王裕貴;Wang,Yu-Kuei
    Contributors: 化學工程與材料工程研究所
    Keywords: 丙烯酸酯;馬來酸酐;抗生物積垢;聚丙烯膜;雙離子性;Zwitterionic;Polypropylene membrane;Anti-fouling;Maleic anhydride;Acrylate
    Date: 2012-08-01
    Issue Date: 2012-09-11 18:12:50 (UTC+8)
    Publisher: 國立中央大學
    Abstract: 雙離子性(zwitterionic)材料為一同時具有正電性電荷及負電性電荷於同一單體而成一電中性的結構,已被證實具有良好的抗生物積垢能力,但不易改質至疏水性材料表面,因此本篇研究擬合成一同時具有疏水性片段與雙離子性結構片段的共聚物,使其疏水性片段得以利用疏水性作用力附著於疏水性聚丙烯(polypropylene, PP)濾膜上,暴露在外的雙離子性結構則用以對抗生物分子的沾黏。本研究選用順丁烯二酸酐(Maleic anhydride, MA),使之與疏水性單體丙烯酸十八酯(octadecyl acrylate, OA)及丙烯酸己酯(hexyl acrylate, HA)於共溶劑下共聚合,再將所得之共聚物再以N,N’-二甲基乙二胺(N,N’-Dimethylethylenediamine, DMEA)開環而形成一同時具有疏水性片段與雙離子性結構片段的共聚物(MAOA-DMEA與MAHA-DMEA),並透過控制不同的共聚合起始劑量以獲得不同分子量共聚物,且藉由核磁共振光譜儀(1H-NMR)分析其化學結構,及以膠體滲透層析儀(GPC)分析其分子量。接著量測經過不同分子量的共聚物改質之PP濾膜對牛血清蛋白(bovine serum albumin, BSA)溶液中的蛋白質吸附變化量,並觀察測試細菌E. coli與S. maltophilia在經共聚物改質後的PP膜上貼附的情形。實驗結果發現經過MAOA-DMEA系列改質的PP緻密膜可降低80%以上的BSA吸附量,且對抵抗E. coli與S. maltophilia的貼附具有一定的能力。雙離子性(zwitterionic)材料為一同時具有正電性電荷及負電性電荷於同一單體而成一電中性的結構,已被證實具有良好的抗生物積垢能力,但不易改質至疏水性材料表面,因此本篇研究擬合成一同時具有疏水性片段與雙離子性結構片段的共聚物,使其疏水性片段得以利用疏水性作用力附著於疏水性聚丙烯(polypropylene, PP)濾膜上,暴露在外的雙離子性結構則用以對抗生物分子的沾黏。本研究選用順丁烯二酸酐(Maleic anhydride, MA),使之與疏水性單體丙烯酸十八酯(octadecyl acrylate, OA)及丙烯酸己酯(hexyl acrylate, HA)於共溶劑下共聚合,再將所得之共聚物再以N,N’-二甲基乙二胺(N,N’-Dimethylethylenediamine, DMEA)開環而形成一同時具有疏水性片段與雙離子性結構片段的共聚物(MAOA-DMEA與MAHA-DMEA),並透過控制不同的共聚合起始劑量以獲得不同分子量共聚物,且藉由核磁共振光譜儀(1H-NMR)分析其化學結構,及以膠體滲透層析儀(GPC)分析其分子量。接著量測經過不同分子量的共聚物改質之PP濾膜對牛血清蛋白(bovine serum albumin, BSA)溶液中的蛋白質吸附變化量,並觀察測試細菌E. coli與S. maltophilia在經共聚物改質後的PP膜上貼附的情形。實驗結果發現經過MAOA-DMEA系列改質的PP緻密膜可降低80%以上的BSA吸附量,且對抵抗E. coli與S. maltophilia的貼附具有一定的能力。Zwitterionic moieties that simultaneously own a positively and a negatively charged groups have been demonstrated to have excellent anti-fouling ability. The remaining problem is how to attach zwitterionic moieties onto the surface of a hydrophobic membrane, such as the polypropylene (PP) membrane. To solve this problem, we try to synthesize amphiphilic zwitterionic copolymers, which compromise both hydrophobic and zwitterionic monomers, onto the PP membranes. Zwitterionic monomers are highly water soluble. It is difficult to find a suitable solvent which simultaneously dissolve hydrophobic and zwitterionic monomers. Therefore, we try to synthesize the copolymers by co-polymerize octadecyl acrylate or hexyl acrylate with maleic anhydride in toluene, and then the maleic anhydride in copolymers are reacted with N,N’-Dimethylethylenediamine (DMEA) to form a zwitterionic moiety containing both carboxylic and N,N’-dimethylethyleneamine. The structures and molecular weight of copolymers have been characterized by NMR and GPC. The effect of molecular weight of copolymers on the antifouling properties of coated membranes are under investigation. The amount of BSA adsorption and bacteria (E. coli and S. maltophilia) adhesion on PP membranes are measured. The experimental results show that the PP dense membrane which modified through the MAOA-DMEA series copolymer can reduce more than 80% of BSA adsorption, and they have certain ability to resist the adhesion of S. maltophilia.
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