手性四氫噻吩配位基的合成及其應用在不對稱催化反應之研究;Studies of Chiral Tetrahydrothiophenes in Asymmetric Catalysis

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/54167

Title:	手性四氫噻吩配位基的合成及其應用在不對稱催化反應之研究;Studies of Chiral Tetrahydrothiophenes in Asymmetric Catalysis
Authors:	吳欣怡;Wu,Hsin-Yi
Contributors:	化學研究所
Keywords:	不對稱催化;四氫噻吩配位基;Asymmetric Catalysis;Tetrahydrothiophenes
Date:	2012-08-28
Issue Date:	2012-09-11 18:38:08 (UTC+8)
Publisher:	國立中央大學
Abstract:	四氫噻吩衍生物 (S)-diphenyl(tetrahydrothiophen-2-yl)methanol (1) 的合成是以市售5-溴戊酸為起始物，經由五步的合成路徑而得。除此之外，我們將探討 (S)-(1) 於不對稱催化領域的應用，如：不對稱環氧化反應、不對稱烯丙基取代反應。在不對稱環氧化的應用上，最佳可以得到反式產物 (34) 92 % e.e；而不對稱烯丙基烷化卅醚化的應用上，仍有改善的空間。A novel chiral tetrahydrothiophene derivative (1) was obtained enantioselectively from commercially available 5-bromopentanoic acid through a 5- step synthetic route. We also demostrated the applications of this chiral ligand in asymmetric sulfur ylide epoxidation and organometallic asymmetric allylic substitution.
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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