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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/5892

    Title: 一、開發組合式藥物合成所需具安全閥(Safety Catch)之鍵鏈劑 二、開發新型紫外光吸收劑;1.A new and versatile Safety-Catch linker for solid phase syntheses 2.Design and syntheses of a series of novel UV asorbers
    Authors: 戴志和;Jr-He Dai
    Contributors: 化學研究所
    Keywords: 鍵鏈劑;安全閥;藥物合成;組合化學;紫外線吸收劑;safety catch;combinatorial chemistry;linker;uv asorber
    Date: 2002-06-27
    Issue Date: 2009-09-22 10:09:43 (UTC+8)
    Publisher: 國立中央大學圖書館
    Abstract: 第一章 在Merrifield樹脂接上一Thiophenol之官能基。選擇採用Alkylation、Addition或Mitsunobu reaction等方法接上不同的substrates並進行所需要的反應,接著利用氧化、Pummer Rearrange與TEA或NaBH4斷裂之三步驟系統反應將產物從樹脂上斷裂下來,最終可以得到Alcohols、Aldehydes、Diols、Peptides…等產物。 第二章 以第二代Hydroxybenzotriazoles系列與第三代Hydroxyphenyltriazine系列產品的結構做為基礎,設計一個新型的UV Absorber,期望可以開發出具有較佳性質與較低生產成本之產品。 Chapter I A new and versatile Safety-Catch linker for solid phase syntheses is described. The phenol group of trityl protected thiophenol was first attached and then after deprotect it, the thiol group of the Safety-Catch linker was alkylated to various of substrates. A the end of each solid phase syntheses sequence, these linkers were activated and cleaved by pummer rearrangement to produce alcohols or aldehydes under two different cleavage conditions. Chapter II We haved designed and synthesized a series of novel UV asorbers based on known commerical products of Hydroxybenzotriazoles and Hydroxyphenyltriazines. These new UV asorbers are expected to have better quality and cost less.
    Appears in Collections:[化學研究所] 博碩士論文

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