含奎寧酸─胞核甘單磷酸類似物之設計及合成; Design and Synthesis of Quinic Acid-Cytidine Monophosphate Aanlogous

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/6013

Title:	含奎寧酸─胞核甘單磷酸類似物之設計及合成;Design and Synthesis of Quinic Acid-Cytidine Monophosphate Aanlogous
Authors:	吳心如;Hsin-ru Wu
Contributors:	化學研究所
Keywords:	奎寧酸;胞核甘單磷酸;唾液酸轉移酶;sialyltransferases;CMP-quinic acid
Date:	2004-07-06
Issue Date:	2009-09-22 10:11:53 (UTC+8)
Publisher:	國立中央大學圖書館
Abstract:	經由唾液酸化而來的醣蛋白及醣脂質，存在於細胞表面，對於癌細胞的轉移扮演著相當重要的角色。根據文獻報導醣類、核甘酸及醣類衍生物的抑制性，針對以予體為基礎的抑制劑，發現核甘酸結構有其存在的必要性，而唾液酸部分則不一定。基於這些已知的預測奎寧酸─核甘單磷酸將對唾液酸轉移酶有其抑制效果，因此設計合成以 Fmoc-Asp(OBut)-OH 或Fmoc-Glu(OBut)-OH 為鏈鍵之奎寧酸─核甘單磷酸類似物。 Sialylation of glycoproteins and glycolipids, which plays an important role in cell surface to cancer cell metastasis. The literatures reported that inhinitors including saccharid, nucleotide, and sugar derivatives displayed the importance and requirement of the cytidine nucleotide toward the inhibition of sialyltransferase, but the sialic acid moiety may not be essential. Base on these report evidence, the non-sialyl framework CMP-quinic acid derivatives will be effective inhibitors of sialyltransferases. Therefore, we utilize such as Fmoc-Asp(OBut)-OH or Fmoc-Glu(OBut)-OH to construct the synthesis of quinic acid-CMP analogues.
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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