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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/6083

    Title: 1,3-偶極環化加成反應在藥物合成與醣晶片上的應用;Application of 1, 3-Dipolar Cycloaddition in Drug Discovery and Sugar Microarray
    Authors: 余聖潔;Sheng-Chieh Yu
    Contributors: 化學研究所
    Keywords: 3-偶極環化加成反應的應用;1;3-Dipolar Cycloaddition;1
    Date: 2005-03-08
    Issue Date: 2009-09-22 10:12:57 (UTC+8)
    Publisher: 國立中央大學圖書館
    Abstract: 本論文為,探討1,3-偶極環化加成反應的應用。在第一部份的目標為合成嚴重呼吸道症候群(Severe Acute Respiratory Syndrome,SARS)冠狀病毒或其他病毒的抑制劑。利用一號位置為β位向的疊氮基核醣與不同的末端炔類進行1,3-偶極環化加成反應,得到60個分子進行篩檢。在第二部份為開發新的晶片表面化學方法,將晶片種上炔類後,再利用1,3-偶級環化加成反應將含有疊氮基的各種小分子種在晶片表面上,以利於作各種檢測的工作。 In this thesis, new application of 1,3-dipolar cycloaddition in the synthesis of nucleotides analogue and preparation of biomolecule microarray were developed. In the first section, a nucleotides library with 60 members were created as inhibitors of SARS coronaviruses or another viruses. By using 1, 3-dipolar cycloaddition, different terminal alkynes reacted with ribofuranosyl azide to give the nucleotides library. In the second section , a new methodology was developed to immobilize small organic molecules on glass slide. The azido compounds were implanted on chip surface with alkyne functionality by 1,3-dipolar cycloaddition.
    Appears in Collections:[化學研究所] 博碩士論文

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