本篇論文分為兩個部分，第一部分是將具有醛基官能基的類沸石咪唑骨架材料，ZIF-90，利用簡單且和緩的後修飾方法，將其表面上的醛基官能基轉換為羧酸以及胺基官能基，得到ZIF-90-C以及ZIF-90-A這兩種微孔洞材料。經過此後修飾可讓ZIF-90-C以及ZIF-90-A在中性條件下分別帶有不同電荷，以便獲得更多的應用性。而ZIF-90-A在吸附二氧化碳中展現了很好的留滯能力，可以做為儲存二氧化碳的材料。此外，修飾上胺基官能基的ZIF-90-A對DNA展現了非常好的吸附能力，這為類沸石咪唑骨架材料開啟了在生物化學領域的應用性，例如生物分子的分離或傳遞。 第二部分是將具有羧酸官能基的中孔洞材料CAR-10，修飾上對人體無毒性且具芳香環的胺基酸：苯丙胺酸、色胺酸，得到產物CAR-10-Phe和CAR-10-Trp，並且利用其苯環間作用力去吸附同樣具有芳香環的毒物，像是巴拉刈 (Paraquat)以及其結構類似物Ethyl viologen dibromide (EVB)。與市售的活性碳材料相比，具芳香環胺基酸的中孔洞材料在中性環境下對巴拉刈展現了非常好的吸附能力，因此可將此材料應用於血液透析，達到解毒的效果。 Two parts in my thesis. Part I, a straightforward method was developed for the conversion ZIF-90 aldehyde groups into amino and carboxyl groups to change the ZIF surface into cationic and anionic, respectively, under neutral conditions. A detailed characterization of the samples performed using different spectroscopic techniques unanimously demonstrated the ZIFs. Accordingly, the transformations proceeded without loss of integrity of the parent framework. Remarkably, ZIF-90-A showed with great CO2 binding capability, so it is good potential material for CO2 storage. In addition, we also have demonstrated the potential of use the ZIFs modified with amino groups for polynucleic acid separation by DNA plasmid binding assays. It opens a new way for the application of ZIF materials in biomaterials separation or delivery. Part II, a general synthetic method for functionalization of mesoporous silica with amino acid has been developed. The carboxylic acid functionalized SBA-15 were conjugated with L-phenylalanine (Phe) and L-tryptophan (Trp) to obtain nontoxic amino acid-conjugated functionalized mesoporous silica materials. The materials were used as adsorbents for the removal of the herbicide Paraquat (PQ) and its analog, ethyl viologen dibromide (EVB) from aqueous solutions. In comparison to the commercially activated carbon adsorbents, the silica-based adsorbents prepared in this study exhibited relatively higher PQ removal efficiency at room temperature and pH 7.0. This bioconjugated method developed here provides a promising new tool to synthesize new materials for detoxification of herbicides in clinical trials.
