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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/6151


    Title: 合成具有光學活性之六氫菸鹼酸(Pipecolic acid);Enaantioselective Synthesis of Pipecolic Acids
    Authors: 洪欣怡;Shin-Yi Hung
    Contributors: 化學研究所
    Keywords: 六氫菸鹼酸;對掌中心;鏡像異構物;enantioselective;chiral center;Pipecolic acid
    Date: 2005-07-11
    Issue Date: 2009-09-22 10:14:08 (UTC+8)
    Publisher: 國立中央大學圖書館
    Abstract: 本論文以D-(–)-2-苯甘胺酸61 作為含有光學輔助基的起始物,經由官能基轉換與修飾後,環化生成噁嗪酮(oxazinone) 59;利用化合物59製備烯醇陰離子進行不對稱碳-碳烷化後,碳-氮烷化並合環形成化合物58,再經由各種不同的親電子基(electrophile)進行第二次烷化與氫化之後,就可以得到在α-碳上有不同取代基的六氫菸鹼酸57。 The synthesis of 57 is based on the chiral oxazinone 59 as a chiral glycine enolate synthon. Asymmetric alkylation of 59 with 1,4-diiodobutane, deprotection and cyclization gave the 4-phenylhexahydropyrido[2,1-c][1,4] oxazin-1-one. Both enantiomers of pipecolic acid and 2-alkyl pipecolic acids were prepared by the epimerization or the second alkylation of 58 followed by hydrogenation.
    Appears in Collections:[化學研究所] 博碩士論文

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